BR351

Modify Date: 2024-02-04 15:29:13

BR351 Structure
BR351 structure
 Common Name BR351
CAS Number 960113-85-3 Molecular Weight 424.49
Density N/A Boiling Point N/A
Molecular Formula C20H25FN2O5S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of BR351


BR351 is a brain penetrant MMP inhibitor with IC50s of 4, 2, 11, 50 nM for MMP2, MMP8, MMP9 and MMP13, respectively[1]. Potential tools for the molecular imaging of activated MMPs with PET[2].

 Names

Name BR351

 BR351 Biological Activity

Description BR351 is a brain penetrant MMP inhibitor with IC50s of 4, 2, 11, 50 nM for MMP2, MMP8, MMP9 and MMP13, respectively[1]. Potential tools for the molecular imaging of activated MMPs with PET[2].
Related Catalog
Target

MMP-9:11 nM (IC50)

MMP-2:4 nM (IC50)

MMP-8:2 nM (IC50)

MMP13:50 nM (IC50)

In Vivo [18F]BR351 Is quickly metabolized in plasma with 20.28% ± 5.41% of intact tracer remaining at 15 minutes postinjection[2].
References

[1]. Wagner S, et al. Novel fluorinated derivatives of the broad-spectrum MMP inhibitors N-hydroxy-2(R)-[[(4-methoxyphenyl)sulfonyl](benzyl)- and (3-picolyl)-amino]-3-methyl-butanamide as potential tools for the molecular imaging of activated MMPs with PET. J Med Chem. 2007 Nov 15;50(23):5752-64.

[2]. Vazquez N, et al. Evaluation of [18 F]BR420 and [18 F]BR351 as radiotracers for MMP-9 imaging in colorectal cancer. J Labelled Comp Radiopharm. 2017 Jan;60(1):69-79.

 Chemical & Physical Properties

Molecular Formula C20H25FN2O5S
Molecular Weight 424.49

 Safety Information

Hazard Codes Xi
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Chemsrc provides BR351(CAS#:960113-85-3) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of BR351 are included as well.>> amp version: BR351

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