Irindalone

Modify Date: 2024-01-14 19:19:06

Irindalone structure	Common Name	Irindalone
	CAS Number	96478-43-2	Molecular Weight	408.51200
	Density	1.219g/cm3	Boiling Point	605.7ºC at 760mmHg
	Molecular Formula	C₂₄H₂₉FN₄O	Melting Point	N/A
	MSDS	N/A	Flash Point	320.1ºC

Use of Irindalone

Irindalone is a novel serotonin 5-HT2 antagonist.

Name	1-[2-[4-[(1R,3S)-3-(4-fluorophenyl)-2,3-dihydro-1H-inden-1-yl]piperazin-1-yl]ethyl]imidazolidin-2-one
Synonym	More Synonyms

Description	Irindalone is a novel serotonin 5-HT2 antagonist.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor Research Areas >> Neurological Disease
Target	5-HT2[1]
In Vitro	Irindalone causes a concentration-related inhibition of serotonin-induced contractions and shifts the serotonin curve to the right. Irindalone is more potent in inhibiting the serotonin-induced contractions. Irindalone has a similar profile in vitro, with a high affinity for serotonin 5-HT2 receptors and about a 10 times lower affinity for α1-adrenoceptors[1].
In Vivo	Irindalone dose dependently lowers the blood pressure in spontaneously hypertensive rats (SHR) and renal hypertensive dogs[1].
References	[1]. Mikkelsen EO, et al. Comparison of the effect of irindalone, a novel serotonin 5-HT2 antagonist and ketanserin on mechanical responses of rat thoracic aorta. Eur J Pharmacol. 1988 Apr 27;149(1-2):145-8.

Density	1.219g/cm3
Boiling Point	605.7ºC at 760mmHg
Molecular Formula	C₂₄H₂₉FN₄O
Molecular Weight	408.51200
Flash Point	320.1ºC
Exact Mass	408.23300
PSA	38.82000
LogP	3.18770
Index of Refraction	1.6
Storage condition	2-8℃

1-chloro-4-(4-flurophenyl)indan structure

1-chloro-4-(4-f...

CAS#:104087-10-7

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Irindalone Structure

Irindalone

CAS#:96478-43-2

Literature: Boegesoe, Klaus P.; Arnt, Joern; Boeck, Vita; Christensen, A. Vibeke; Hyttel, John; Jensen, Klaus Gundertofte Journal of Medicinal Chemistry, 1988 , vol. 31, # 12 p. 2247 - 2256

1-(2-Chlorethyl)imidazolidin-2-on structure

1-(2-Chlorethyl...

CAS#:2387-20-4

trans-1-[3-(4-fluorophenyl)indan-1-yl]piperazine structure

trans-1-[3-(4-f...

CAS#:104887-11-8

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Irindalone Structure

Irindalone

CAS#:96478-43-2

Literature: Boegesoe, Klaus P.; Arnt, Joern; Boeck, Vita; Christensen, A. Vibeke; Hyttel, John; Jensen, Klaus Gundertofte Journal of Medicinal Chemistry, 1988 , vol. 31, # 12 p. 2247 - 2256

Precursor 3
CAS#:104087-10-7 1-chloro-4-(4-f... CAS#:2387-20-4 1-(2-Chlorethyl... CAS#:104887-11-8 trans-1-[3-(4-f...
DownStream 0

Irindalona

Irindalone

Irindalonum

UNII-4F39T8N10K

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China
Product Name: Irindalone
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Irindalone
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Purity: 98.0%
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