LY 163443

Modify Date: 2024-01-10 12:54:37

LY 163443 structure	Common Name	LY 163443
	CAS Number	97581-70-9	Molecular Weight	366.41400
	Density	1.259g/cm3	Boiling Point	607.7ºC at 760 mmHg
	Molecular Formula	C₂₀H₂₂N₄O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	321.3ºC

Use of LY 163443

LY 163443 is a selective antagonist of leukotrienes D4 (LTD4) and E4 (LTE4). LY 163443 can antagonize LTD4-induced contractions of guinea pig ileum, trachea, and lung parenchyma. LY 163443 also inhibits tracheal contractions to LTE4[1][2].

Name	1-[2-hydroxy-3-propyl-4-[[4-(2H-tetrazol-5-ylmethyl)phenoxy]methyl]phenyl]ethanone
Synonym	More Synonyms

Description	LY 163443 is a selective antagonist of leukotrienes D4 (LTD4) and E4 (LTE4). LY 163443 can antagonize LTD4-induced contractions of guinea pig ileum, trachea, and lung parenchyma. LY 163443 also inhibits tracheal contractions to LTE4[1][2].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Leukotriene Receptor Research Areas >> Inflammation/Immunology
References	[1]. Fleisch JH, et, al. Evaluation of LY163443, 1-[2-hydroxy-3-propyl-4-([4- (1H-tetrazol-5-ylmethyl)phenoxy]methyl) phenyl]ethanone, as a pharmacologic antagonist of leukotrienes D4 and E4. Naunyn Schmiedebergs Arch Pharmacol. 1986 May;333(1):70-7. [2]. Bitterman H, et, al. Use of a novel peptide leukotriene receptor antagonist, Ly-163443, in splanchnic artery occlusion shock. Prostaglandins Leukot Essent Fatty Acids. 1988 May;32(2):63-70.

Description

Related Catalog

Signaling Pathways >> GPCR/G Protein >> Leukotriene Receptor

Research Areas >> Inflammation/Immunology

References

[1]. Fleisch JH, et, al. Evaluation of LY163443, 1-[2-hydroxy-3-propyl-4-([4- (1H-tetrazol-5-ylmethyl)phenoxy]methyl) phenyl]ethanone, as a pharmacologic antagonist of leukotrienes D4 and E4. Naunyn Schmiedebergs Arch Pharmacol. 1986 May;333(1):70-7.

[2]. Bitterman H, et, al. Use of a novel peptide leukotriene receptor antagonist, Ly-163443, in splanchnic artery occlusion shock. Prostaglandins Leukot Essent Fatty Acids. 1988 May;32(2):63-70.

Density	1.259g/cm3
Boiling Point	607.7ºC at 760 mmHg
Molecular Formula	C₂₀H₂₂N₄O₃
Molecular Weight	366.41400
Flash Point	321.3ºC
Exact Mass	366.16900
PSA	100.99000
LogP	3.23020
Index of Refraction	1.615

N/A

CAS#:97581-58-3

~67%

LY 163443

CAS#:97581-70-9

Literature: Dillard, Robert D.; Carr, F. Patrick; McCullough, Doris; Haisch, Klaus D.; Rinkema, Lynn E.; Fleisch, Jerome H. Journal of Medicinal Chemistry, 1987 , vol. 30, # 5 p. 911 - 918

4-Hydroxyphenyl...

CAS#:14191-95-8

LY 163443

CAS#:97581-70-9

Literature: Dillard, Robert D.; Carr, F. Patrick; McCullough, Doris; Haisch, Klaus D.; Rinkema, Lynn E.; Fleisch, Jerome H. Journal of Medicinal Chemistry, 1987 , vol. 30, # 5 p. 911 - 918

Ethanone, 1-[4-...

CAS#:97582-36-0

LY 163443

CAS#:97581-70-9

Literature: Dillard, Robert D.; Carr, F. Patrick; McCullough, Doris; Haisch, Klaus D.; Rinkema, Lynn E.; Fleisch, Jerome H. Journal of Medicinal Chemistry, 1987 , vol. 30, # 5 p. 911 - 918

4-acetyl-1-(N,N...

CAS#:97582-29-1

LY 163443

CAS#:97581-70-9

Literature: Dillard, Robert D.; Carr, F. Patrick; McCullough, Doris; Haisch, Klaus D.; Rinkema, Lynn E.; Fleisch, Jerome H. Journal of Medicinal Chemistry, 1987 , vol. 30, # 5 p. 911 - 918

Precursor 2
CAS#:14191-95-8 4-Hydroxyphenyl... CAS#:97582-36-0 Ethanone, 1-[4-...
DownStream 0

5-[4-(4-Acetyl-3-hydroxy-2-propylbenzyloxy)benzyl]-tetrazole

1-(2-Hydroxy-3-propyl-4-((4-(1H-tetrazol-5-ylmethyl)phenoxy)methyl)phenyl)ethanone

Ethanone,1-(2-hydroxy-3-propyl-4-((4-(1H-tetrazol-5-ylmethyl)phenoxy)methyl)phenyl)

LY 163443

Use of LY 163443

Names

LY 163443 Biological Activity

Chemical & Physical Properties

Synthetic Route

Precursor & DownStream

Synonyms