(Des-Gly77,Des-His78)-Myelin Basic Protein (68-84) (guinea pig)

Modify Date: 2024-01-02 11:00:53

(Des-Gly77,Des-His78)-Myelin Basic Protein (68-84) (guinea pig) structure	Common Name	(Des-Gly77,Des-His78)-Myelin Basic Protein (68-84) (guinea pig)
	CAS Number	98474-59-0	Molecular Weight	1736.79000
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₇₁H₁₁₃N₂₃O₂₈	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	N/A

Use of (Des-Gly77,Des-His78)-Myelin Basic Protein (68-84) (guinea pig)

Myelin Basic Protein (MBP) (68-82), guinea pig is a fragment of myelin basic protein (MBP).

Name	tyr-gly-ser-leu-pro-gln-lys-ser-gln-arg-ser-gln-asp-glu-asn
Synonym	More Synonyms

Description	Myelin Basic Protein (MBP) (68-82), guinea pig is a fragment of myelin basic protein (MBP).
Related Catalog	Signaling Pathways >> Others >> Others Peptides Research Areas >> Inflammation/Immunology
In Vitro	Multiple sclerosis is the most common autoimmune disorder affecting the central nervous system. In this study, whole blood samples are analyzed for activation capacity and the activatability of CD4+ and CD8+ T-lymphocytes by human total myelin basic protein (MBP), human MBP 104-118 fragment, and guinea pig MBP (68-82) fragment. A significant increase in the number of activated T-lymphocytes was observed in the whole blood. For all three tested MBPs, this increase in activated CD4+ and CD8+ T-lymphocytes is statistically significant (p<0.01). However, this increase in activated T-cells is most prominent following incubation with human total MBP, followed by human 104-118 fragment; the smallest increase is observed following incubation with guinea pig MBP (68-82) fragment (human total MBP>huMBP-104-118>guinea pig MBP (68-82))[1].
In Vivo	Whether pretreatment with bee venom acupuncture (BVA) from the same day of MBP (68-82) immunization can affect the induction and progression of experimental autoimmune encephalomyelitis (EAE) and weight loss is examined. At 5-9 days after immunization, rats in the myelin basic protein (MBP) group start displaying partial loss of tail tonus (clinical signs, 0.5) in a freely moving environment. At 10-16 days after immunization, most of the rats in the MBP group display more severe symptoms of neurological deficit including paraparesis of the hindlimb, paraplegia, tetraparesis, and tetraplegia. In contrast, rats in the MBP + BVA group display relatively slight neurological deficits in a dose-dependent manner at 11-15 days after immunization, compared to the rats in the MBP group. The onset of symptoms is slightly delayed (BVA 0.8 mg/kg, 6.4±0.6 days) and the maximal clinical score is markedly decreased (BVA 0.25 mg/kg, 3.7±0.2; BVA 0.8 mg/kg, 2.8±0.3), compared to that in the MBP group. At this time, the mean body weight of rats in the MBP group is decreased as compared to that of rats in the normal group, but it is significantly increased in rats of the MBP + BVA group as compared to rats in the MBP group[2].
Kinase Assay	For each individual, the whole blood sample is typically divided into six 1 mL aliquots/tubes. Concanavalin A is added to tube 1 (positive control). Tube 2 is left untreated. Tube 3 is treated with human albumin as a negative control. Human total MBP, human MBP 104-118 fragment and guinea pig MBP (68-82) are added to tubes 4, 5 and 6, respectively. All proteins are added to a final concentration of 2 µg/mL. All experiments (incubations and flow cytometric analysis) are performed in duplicate for each subject[1].
Animal Admin	Rats[2] Ten-week-old female Lewis rats are divided into the following two experimental groups: BVA-pretreated (every 3 days from 20 min before immunization) and BVA-posttreated (daily from days 10-15 after immunization) groups. Each experimental group is subdivided into the following five groups: normal [saline, subcutaneous (s.c.)+saline, s.c.], MBP [250 μg of myelin basic protein MBP (68-82), s.c.+saline, s.c., ST36 acupoint], MBP+BVA 0.25 [250 μg of MBP (68-82), s.c.+0.25 mg/kg body weight of BV, s.c., ST36 acupoint], MBP+BVA 0.8 [250 μg of MBP (68-82), s.c.+0.8 mg/kg body weight of BV, s.c., ST36 acupoint], and BVA alone [saline, s.c.+0.8 mg/kg body weight of BV, s.c., ST36 acupoint] groups. EAE is induced with an emulsion containing 250 μg of MBP (68-82) and 100 μg of Mycobacterium M. tuberculosis per mL of incomplete Freund’s adjuvant. A total of 0.2 mL of this emulsion is injected s.c. into the two hind footpads of rats except for those in the normal group and BVA alone group. Additionally, rats receive intraperitoneal (i.p.) injections of 200 ng of pertussis toxin on days 0 and 2. Rats in the normal group are treated with saline alone instead of MBP (68-82) peptide, pertussis toxin, or BVA[2].
References	[1]. Arneth B. Early activation of CD4⁺ and CD8⁺ T lymphocytes by myelin basic protein in subjects with MS. J Transl Med. 2015 Nov 2;13:341. [2]. Lee MJ, et al. Bee Venom Acupuncture Alleviates Experimental Autoimmune Encephalomyelitis by Upregulating Regulatory T Cells and Suppressing Th1 and Th17 Responses. Mol Neurobiol. 2016 Apr;53(3):1419-1445.

Molecular Formula	C₇₁H₁₁₃N₂₃O₂₈
Molecular Weight	1736.79000
Exact Mass	1735.81000
PSA	877.73000
Storage condition	−20°C

MSDS(Chinese)

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	T+
RIDADR	NONH for all modes of transport
WGK Germany	3

MYELIN BASIC PROTEIN FRAGMENT 68-82 GUINEA PIG

DES-[GLY77,HIS78] MYELIN BASIC PROTEIN (68-84),BOVINE

myelin basic protein guinea pig fragment 68-82

(Des-Gly77,Des-His78)-MBP (68-84) (bovine)

MYELIN BASIC PROTEIN MBP (68-82),GUINEA PIG

MYELIN BASIC PROTEIN (68-82),GUINEA PIG

MFCD00076871

MYELIN BASIC PROTEIN,FRAGMENT 68-82

(Des-Gly77,Des-His78)-MBP (68-84) (guinea pig)

DES[GLY77,HIS78]-MYELIN BASIC PROTEIN,FRAGMENT 68-64

des-Gly77

Myelin Basic Protein (68-82), guinea pig

Myelin Basic Protein (MBP) (68-82), guinea pig

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: MyelinBasicProteinGuineaPigFragment68-82
Price: Click To Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

GL Biochem (Shanghai) Ltd.
China
Product Name: Myelin Basic Protein (68-82), guinea pig
Price: $Inquiry/1g
Purity: 98.0%
Delivery: Inquiry
Contact: Jackie Yang
Email: ymbetter@glbiochem.com

Taiwan Oyi peptide Co. Ltd
China
Product Name: (Des-Gly77,Des-His78)-Myelin Basic Protein (68-84) (guinea pig)
Price: $Inquiry/1mg $Inquiry/100kg
Purity: 98.0%
Delivery: 1 Day
Contact: Vinnie
Email: Jamie@api-made.com

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