Methyl 4-hydroxybenzoate

Modify Date: 2024-01-01 19:14:13

Methyl 4-hydroxybenzoate structure	Common Name	Methyl 4-hydroxybenzoate
	CAS Number	99-76-3	Molecular Weight	152.147
	Density	1.2±0.1 g/cm3	Boiling Point	265.5±13.0 °C at 760 mmHg
	Molecular Formula	C₈H₈O₃	Melting Point	125-128 °C(lit.)
	MSDS	Chinese USA	Flash Point	116.4±12.6 °C

Use of Methyl 4-hydroxybenzoate

Methyl Paraben, isolated from the barks of Tsuga dumosa the methyl ester of p-hydroxybenzoic acid, is a standardized chemical allergen. Methyl Paraben is a stable, non-volatile compound used as an antimicrobial preservative in foods, drugs and cosmetics. The physiologic effect of Methyl Paraben is by means of increased histamine release, and cell-mediated immunity[1].

Name	methylparaben
Synonym	More Synonyms

Description	Methyl Paraben, isolated from the barks of Tsuga dumosa the methyl ester of p-hydroxybenzoic acid, is a standardized chemical allergen. Methyl Paraben is a stable, non-volatile compound used as an antimicrobial preservative in foods, drugs and cosmetics. The physiologic effect of Methyl Paraben is by means of increased histamine release, and cell-mediated immunity[1].
Related Catalog	Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection Natural Products >> Phenols
References	[1]. Soni MG, et al. Evaluation of the health aspects of methyl paraben: a review of the published literature. Food Chem Toxicol. 2002 Oct;40(10):1335-73.

Density	1.2±0.1 g/cm3
Boiling Point	265.5±13.0 °C at 760 mmHg
Melting Point	125-128 °C(lit.)
Molecular Formula	C₈H₈O₃
Molecular Weight	152.147
Flash Point	116.4±12.6 °C
Exact Mass	152.047348
PSA	46.53000
LogP	1.87
Vapour Pressure	0.0±0.6 mmHg at 25°C
Index of Refraction	1.547
Stability	Stable. Incompatible with strong oxidizing agents, strong bases.
Freezing Point	131℃

Methyl 4-hydroxybenzoate MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DH2450000

CHEMICAL NAME :: Benzoic acid, p-hydroxy-, methyl ester

CAS REGISTRY NUMBER :: 99-76-3

BEILSTEIN REFERENCE NO. :: 0509801

LAST UPDATED :: 199701

DATA ITEMS CITED :: 13

MOLECULAR FORMULA :: C8-H8-O3

MOLECULAR WEIGHT :: 152.16

WISWESSER LINE NOTATION :: QR DVO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >8 gm/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - ataxia

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 960 mg/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - somnolence (general depressed activity) Behavioral - ataxia

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 6 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 3 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Rodent - hamster Fibroblast

DOSE/DURATION :: 500 mg/L

REFERENCE :: ESKHA5 Eisei Shikenjo Hokoku. Bulletin of the Institute of Hygienic Sciences. (Kokuritsu Eisei Shikenjo Kagaku, 18-1 Bushitsu Johobu, Setagaya-ku, Tokyo 158, Japan) V.1- 1886- Volume(issue)/page/year: (96),55,1978 *** REVIEWS *** TOXICOLOGY REVIEW ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 4,575,1954 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80461 No. of Facilities: 4469 (estimated) No. of Industries: 33 No. of Occupations: 50 No. of Employees: 57029 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80461 No. of Facilities: 15369 (estimated) No. of Industries: 94 No. of Occupations: 117 No. of Employees: 590361 (estimated) No. of Female Employees: 398916 (estimated)

Hazard Statements	H412
Precautionary Statements	P273
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi,Xn
Risk Phrases	R36/37/38
Safety Phrases	S26-S36-S24/25
RIDADR	UN 2769
WGK Germany	1
RTECS	DH2450000
HS Code	2918290000

Precursor 10
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DownStream 10
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CAS#:3753-81-9 1 3-BIS(P-CARBO... CAS#:35826-59-6 4-ISOPROPOXYBEN...

HS Code	2918290000
Summary	HS: 2918290000 other carboxylic acids with phenol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) VAT:17.0% MFN tariff:6.5% General tariff:30.0%

The complex contributions of genetics and nutrition to immunity in Drosophila melanogaster.

PLoS Genet. 11(3) , e1005030, (2015)

Both malnutrition and undernutrition can lead to compromised immune defense in a diversity of animals, and "nutritional immunology" has been suggested as a means of understanding immunity and determin...

Development and validation of a stability-indicating LC-UV method for the determination of pantethine and its degradation product based on a forced degradation study.

J. Pharm. Biomed. Anal. 97 , 141-50, (2014)

Pantethine (d-bis-(N-pantothenyl-β-aminoethyl)-disulfide, PAN), the stable disulfide form of pantetheine, has beneficial effects in vascular diseases being able to decrease the hyperlipidaemia, modera...

Comparison of rheological properties, follicular penetration, drug release, and permeation behavior of a novel topical drug delivery system and a conventional cream.

Eur. J. Pharm. Biopharm. 88(3) , 614-24, (2015)

A novel adapalene-loaded solid lipid microparticle (SLMA) dispersion as a topical drug delivery system (TDDS) for follicular penetration has been introduced. The objective of the present study was to ...

methyl p-hydroxybenzoate

4-Hydroxybenzoic acid, methyl ester

4-(Carbomethoxy)phenol

Mekkings M

Benzoic acid, 4-hydroxy-, methyl ester

Methylparaben

4-(Methoxycarbonyl)phenol

Methyl parahydroxybenzoate

Killitol

Methyl chemosept

Methyl-4-hydroxybenzoate

p-Hydroxybenzoic acid methyl ester

methyl para-hydroxybenzoate

4-Hydroxybenzoic Acid Methyl Ester

EINECS 202-785-7

Methyl 4-hydroxybenzoate

Benzoic acid, p-hydroxy-, methyl ester

Nipagin

4-Hydroxy-benzoic acid methyl ester

Metagin

p-Hydroxybenzoic acid, methyl ester

p-Hydroxybenzoic methyl ester

Methyl parasept

Tegosept M

4-Hydroxybenzoic acid methylester

MFCD00002352

Methyl Paraben

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Methyl 4-hydroxybenzoate

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