Kushenol C

Modify Date: 2024-01-17 18:20:04

Kushenol C Structure
Kushenol C structure
 Common Name Kushenol C
CAS Number 99119-73-0 Molecular Weight 438.47000
Density N/A Boiling Point N/A
Molecular Formula C25H26O7 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Kushenol C


Kushenol C, isolated from the roots of Sophora flavescens, shows anti-Inflammatory and anti-oxidative stress activities. Kushenol C inhibits BACE1 (β-site APP cleaving enzyme 1) with an IC50 of 5.45 µM[1][2].

 Names

Name Kushenol C
Synonym More Synonyms

 Kushenol C Biological Activity

Description Kushenol C, isolated from the roots of Sophora flavescens, shows anti-Inflammatory and anti-oxidative stress activities. Kushenol C inhibits BACE1 (β-site APP cleaving enzyme 1) with an IC50 of 5.45 µM[1][2].
Related Catalog
In Vitro Kushenol C dose-dependently suppresses the production of inflammatory mediators, including NO, PGE2, IL-6, IL1β, MCP-1, and IFN-β in LPS-stimulated RAW264.7 macrophages. Kushenol C (50-100 µM;) significantly decreases the phosphorylation of both STAT1 molecules and STAT6 in a dose-dependent manner in LPS-stimulated RAW264.7 cells[1]. Kushenol C upregulates the expression of HO-1 and its activities in the LPS-stimulated RAW264.7 macrophages. In HaCaT cells, Kushenol C prevents DNA damage and cell death by upregulating the endogenous antioxidant defense system involving glutathione, superoxide dismutase, and catalase, which prevents reactive oxygen species production from tert-butyl hydroperoxide (tBHP)-induced oxidative stress in HaCaT cells[1]. Kushenol C inhibits BChE and AChE with IC50s of 54.86 and 33.13 µM[2].
References

[1]. Cho BO, et al. In vitro Anti-Inflammatory and Anti-Oxidative Stress Activities of Kushenol C Isolated from the Roots of Sophoraflavescens. Molecules. 2020;25(8):1768. Published 2020 Apr 12.

[2]. Jung HA, et al. Selective inhibition of prenylated flavonoids from Sophora flavescens against BACE1 and cholinesterases. Am J Chin Med. 2010;38(2):415-429.

 Chemical & Physical Properties

Molecular Formula C25H26O7
Molecular Weight 438.47000
Exact Mass 438.16800
PSA 131.36000
LogP 5.07910

 Synonyms

kushenol C
2-(2,4-Dihydroxy-phenyl)-3,5,7-trihydroxy-8-(2-isopropenyl-5-methyl-hex-4-enyl)-chromen-4-one
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