ubiquinol-10

Modify Date: 2024-01-07 17:19:18

ubiquinol-10 Structure
ubiquinol-10 structure
Common Name ubiquinol-10
CAS Number 992-78-9 Molecular Weight 865.359
Density 1.0±0.1 g/cm3 Boiling Point 866.9±65.0 °C at 760 mmHg
Molecular Formula C59H92O4 Melting Point 48-49ºC
MSDS N/A Flash Point 478.1±34.3 °C

 Use of ubiquinol-10


Ubiquinol (Ubiquinol-10) is a reduced form of coenzyme Q10 (CoQ10). Ubiquinol is a potent antioxidant that has the capacity to protect Vitamin E, and also helps to regenerate depleted vitamin E and Vitamin C. Ubiquinol is both lipophilic and hydrophilic and acts as transmembrane factor preventing lipid peroxidation and propagation by transferring electrons to ROS[1][2][3].

 Names

Name Ubiquinol,Dihydrocoenzyme Q10
Synonym More Synonyms

 ubiquinol-10 Biological Activity

Description Ubiquinol (Ubiquinol-10) is a reduced form of coenzyme Q10 (CoQ10). Ubiquinol is a potent antioxidant that has the capacity to protect Vitamin E, and also helps to regenerate depleted vitamin E and Vitamin C. Ubiquinol is both lipophilic and hydrophilic and acts as transmembrane factor preventing lipid peroxidation and propagation by transferring electrons to ROS[1][2][3].
Related Catalog
In Vitro The lipophilic environment encircles the lipophilic low-molecular-weight antioxidants (α-tocopherol, β-carotene, and Ubiquinol) and prevents them from reacting as skin protectors[1]. Oxidative stress is defined as a disturbance in the prooxidant-antioxidant balance in favor of the former and has been suggested to be a relevant factor in aging as well as in different pathological conditions, such as heart attack, diabetes, and cancer. Ubiquinol is very sensitive against oxygen radicals and gives ubiquinone as an oxidation product. Therefore, the ratio of ubiquinol to ubiquinone should be a good marker of oxidative stress because of its definition[2].
In Vivo The oxidized (UQox) and reduced (Ubiquinol) forms of ubiquinone (UQ) homologues in rat tissues and subcellular fractionsare analyzed. The levels of these homologues are highest in heart with lesser amounts occurring in kidney, liver and other organs. In liver and blood plasma, the UQred homologue amounted to 70-80% of the total UQ (UQox + Ubiquinol = t-UQ). Ubiquinol is less than 30% of t-UQ in other tissues and blood cells. t-UQ is much higher in leukocytes and platelets in blood than in erythrocytes. In erythrocytes, t-UQ is exclusively located in the cell membranes.Ubiquinol is also found in all subcellular fractions isolated from liver and kidney in about the same ratio as Ubiquinol/t-UQ is present in the whole organ. The levels of Ubiquinol per mg protein in subcellular fractions from liver is highest in mitochondria, with lesser amounts present in plasma membranes, lysosomes, Golgi complex, nuclei, microsomes and cytosol. In the mitochondria, the outer membranes are richer in t-UQ than the inner membranes[4].
References

[1]. Grammenandi K, et al. Low-Molecular-Weight Hydrophilic and Lipophilic Antioxidants in Nonmelanoma Skin Carcinomas and Adjacent Normal-Looking Skin. Skin Pharmacol Physiol. 2016;29(6):324-331.

[2]. Yamamoto Y, et al. Plasma ratio of ubiquinol and ubiquinone as a marker of oxidative stress. Mol Aspects Med. 1997;18 Suppl:S79-84.

[3]. Zhang Y, et al. Ubiquinol is superior to ubiquinone to enhance Coenzyme Q10 status in older men. Food Funct. 2018 Nov 14;9(11):5653-5659.

[4]. Takahashi T, et al. Distribution of ubiquinone and ubiquinol homologues in rat tissues and subcellular fractions. Lipids. 1993 Sep;28(9):803-9.

 Chemical & Physical Properties

Density 1.0±0.1 g/cm3
Boiling Point 866.9±65.0 °C at 760 mmHg
Melting Point 48-49ºC
Molecular Formula C59H92O4
Molecular Weight 865.359
Flash Point 478.1±34.3 °C
Exact Mass 864.699585
PSA 58.92000
LogP 21.06
Vapour Pressure 0.0±0.3 mmHg at 25°C
Index of Refraction 1.526

 Safety Information

RIDADR NONH for all modes of transport

 Articles1

More Articles
Topical treatment with coenzyme Q10-containing formulas improves skin's Q10 level and provides antioxidative effects.

Biofactors 41 , 383-90, (2016)

Ubiquinone (coenzyme Q10, Q10) represents an endogenously synthesized lipid-soluble antioxidant which is crucial for cellular energy production but is diminished with age and under the influence of ex...

 Synonyms

ubiquinol Q10
ubiquinol-10
2-[(2E,6E,10E,14E,18E,22E,26E,30E,34E)-3,7,11,15,19,23,27,31,35,39-DecaMethyl -2,6,10,14,18
1-((2E,6E,10E,14E,18E,22E,26E,30E,34E)-3,7,11,15,19,23,27,31,35,39-decamethyltetraconta-2,6,10,14,18,22,26,30,34,38-decaenyl)-5,6-dimethoxy-3-methylbenzene-1,4-diol
2-[(2E,6E,10E,14E,18E,22E,26E,30E,34E)-3,7,11,15,19,23,27,31,35,39-Decamethyl-2,6,10,14,18,22,26,30,34,38-tetracontadecenyl]-5,6-dimethoxy-3-methylbenzene-1,4-diol
Reduced Coenzyme Q10
2-[(2E,6E,10E,14E,18E,22E,26E,30E,34E)-3,7,11,15,19,23,27,31,35,39-Decamethyl-2,6,10,14,18,22,26,30,34,38-tetracontadecaen-1-yl]-5,6-dimethoxy-3-methyl-1,4-benzenediol
1,4-Benzenediol, 2-[(2E,6E,10E,14E,18E,22E,26E,30E,34E)-3,7,11,15,19,23,27,31,35,39-decamethyl-2,6,10,14,18,22,26,30,34,38-tetracontadecaen-1-yl]-5,6-dimethoxy-3-methyl-
Ubiquinol 50
UBIQUINOL (Reduced coenzyme Q10)
Reduced Ubiquinone Q10
2-[(2E,6E,10E,14E,18E,22E,26E,30E,34E)-3,7,11,15,19,23,27,31,35,39-Decamethyl-2,6,10,14,18,22,26,30,34,38-tetracontadecenyl]-5,6-dimethoxy-3-methylhydroquinone
Dihydrocoenzyme Q10
Reduced ubiquinone-10
coenzyme Q10-H2
Top Suppliers:I want be here




Get all suppliers and price by the below link:

ubiquinol-10 suppliers

ubiquinol-10 price