PKI (5-24)

Modify Date: 2024-01-02 17:38:59

PKI (5-24) structure	Common Name	PKI (5-24)
	CAS Number	99534-03-9	Molecular Weight	2222.38000
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₉₄H₁₄₈N₃₂O₃₁	Melting Point	N/A
	MSDS	USA	Flash Point	N/A

Use of PKI (5-24)

PKI(5-24) is a potent, competitive, and synthetic peptide inhibitor of PKA (cAMP-dependent protein kinase), with a Ki of 2.3 nM. PKI(5-24) corresponds to residues 5-24 in the naturally occurring heat-stable protein kinase inhibitor[1][2].

Name	h-thr-thr-tyr-ala-asp-phe-ile-ala-ser-gly-arg-thr-gly-arg-arg-asn-ala-ile-his-asp-oh
Synonym	More Synonyms

Description	PKI(5-24) is a potent, competitive, and synthetic peptide inhibitor of PKA (cAMP-dependent protein kinase), with a Ki of 2.3 nM. PKI(5-24) corresponds to residues 5-24 in the naturally occurring heat-stable protein kinase inhibitor[1][2].
Related Catalog	Signaling Pathways >> Protein Tyrosine Kinase/RTK >> PKA Research Areas >> Others Signaling Pathways >> Stem Cell/Wnt >> PKA
In Vitro	PKI(5-24) is a 20-residue peptide has been synthesized that corresponds to the active site of the skeletal muscle inhibitor protein[1]. PKI(5-24) inhibits phosphotransferase activity of the mutant cGMP kinase with higher potency than that of wild type, with Ki values of 42 μΜ and 160 μΜ, respectively[2].
References	[1]. Cheng HC, et al. A potent synthetic peptide inhibitor of the cAMP-dependent protein kinase. J Biol Chem. 1986;261(3):989-992. [2]. Ruth P, et al F. A cGMP kinase mutant with increased sensitivity to the protein kinase inhibitor peptide PKI(5-24). Biol Chem. 1996;377(7-8):513-520.

Molecular Formula	C₉₄H₁₄₈N₃₂O₃₁
Molecular Weight	2222.38000
Exact Mass	2221.10000
PSA	1049.44000

PKI (5-24) MSDS(Chinese)

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport

A potent synthetic peptide inhibitor of the cAMP-dependent protein kinase.

J. Biol. Chem. 261 , 989, (1986)

As an important new reagent for studying the cAMP-dependent protein kinase, a 20-residue peptide has been synthesized that corresponds to the active site of the skeletal muscle inhibitor protein. This...

Effects of endoplasmic reticulum stress on group VIA phospholipase A2 in beta cells include tyrosine phosphorylation and increased association with calnexin.

J. Thorac. Cardiovasc. Surg. 285 , 33843-57, (2010)

The Group VIA phospholipase A(2) (iPLA(2)β) hydrolyzes glycerophospholipids at the sn-2-position to yield a free fatty acid and a 2-lysophospholipid, and iPLA(2)β has been reported to participate in a...

Release of Ca2+ by inositol 1,4,5-trisphosphate in platelet membrane vesicles is not dependent on cyclic AMP-dependent protein kinase.

Biochem. J. 257(3) , 715-21, (1989)

In contrast with previous reports, it was found that membrane-protein phosphorylation by the catalytic subunit (CS) of cyclic AMP-dependent protein kinase had no effect on Ca2+ uptake into platelet me...

PROTEIN KINASE INHIBITOR RABBIT

ip20

TTYADFIASGRTGRRNAIHD

PROTEIN KINASE A INHIBITOR 5-24

protein kinase inhibitor from rabbit

H-TTYADFIASGRTGRRNAIHD