TI17

Modify Date: 2024-01-20 18:40:40

TI17 structure	Common Name	TI17
	CAS Number	1005178-02-8	Molecular Weight	374.43
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₃H₂₂N₂O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of TI17

TI17 is an inhibitor of the thyroid hormone receptor-interacting protein Trip13 and has anticancer activity. TI17 effectively inhibits multiple myeloma (MM) cell proliferation and induces cell cycle arrest and apoptosis. Trip13 is an AAA-ATPase that mediates double-strand break (DSB) repair; TI17 inhibits Trip13 function and increases DNA damage[1].

Name	TI17

Description	TI17 is an inhibitor of the thyroid hormone receptor-interacting protein Trip13 and has anticancer activity. TI17 effectively inhibits multiple myeloma (MM) cell proliferation and induces cell cycle arrest and apoptosis. Trip13 is an AAA-ATPase that mediates double-strand break (DSB) repair; TI17 inhibits Trip13 function and increases DNA damage[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Others >> Thyroid Hormone Receptor
Target	Thyroid hormone receptor interacting protein 13 (Trip13)[1]
References	[1]. Chang S et al. TI17, a novel compound, exerts anti-MM activity by impairing Trip13 function of DSBs repair and enhancing DNA damage. Cancer Med. 2023 Nov 9.

Molecular Formula	C₂₃H₂₂N₂O₃
Molecular Weight	374.43

TI17

Use of TI17

Names

TI17 Biological Activity

Chemical & Physical Properties