Oxcarbazepine-D4

Modify Date: 2024-01-11 15:53:55

Oxcarbazepine-D4 structure	Common Name	Oxcarbazepine-D4
	CAS Number	1020719-71-4	Molecular Weight	252.26800
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₅H₁₂N₂O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Oxcarbazepine-D4

Oxcarbazepine-D4 (GP 47680-D4) is the deuterium labeled Oxcarbazepine. Oxcarbazepine is a sodium channel blocker[1]. Oxcarbazepine significantly inhibits glioblastoma cell growth and induces apoptosis or G2/M arrest in glioblastoma cell lines[2]. Anti-cancer and anticonvulsant effects[2][3].

Name	1,2,3,4-tetradeuterio-6-oxo-5H-benzo[b][1]benzazepine-11-carboxamide
Synonym	More Synonyms

Description	Oxcarbazepine-D4 (GP 47680-D4) is the deuterium labeled Oxcarbazepine. Oxcarbazepine is a sodium channel blocker[1]. Oxcarbazepine significantly inhibits glioblastoma cell growth and induces apoptosis or G2/M arrest in glioblastoma cell lines[2]. Anti-cancer and anticonvulsant effects[2][3].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Research Areas >> Neurological Disease
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Ashley M Thomas, et al. Old Friends With New Faces: Are Sodium Channel Blockers the Future of Adjunct Pain Medication Management?J Pain. 2018 Jan;19(1):1-9. [3]. Ching-Yi Lee,et al. The effects of antiepileptic drugs on the growth of glioblastoma cell lines. J Neurooncol. 2016 May;127(3):445-53. [4]. M Schmutz, et al. Oxcarbazepine: preclinical anticonvulsant profile and putative mechanisms of action. Epilepsia. 1994;35 Suppl 5:S47-50.

Molecular Formula	C₁₅H₁₂N₂O₂
Molecular Weight	252.26800
Exact Mass	252.09000
PSA	63.40000
LogP	3.40750

Oxacarbazepine-d4

[2H4]-Oxcarbazepine

Oxetol-d4

Oxecarb-d4

Oxcarbazepine-D4 (Major)

Trileptal-d4

Aurene-d4

Oxcarbazepine-D4

Use of Oxcarbazepine-D4

Names

Oxcarbazepine-D4 Biological Activity

Chemical & Physical Properties

Synonyms