Prasugrel-d4

Modify Date: 2024-04-05 17:41:29

Prasugrel-d4 Structure
Prasugrel-d4 structure
Common Name Prasugrel-d4
CAS Number 1189919-49-0 Molecular Weight 377.46600
Density N/A Boiling Point N/A
Molecular Formula C20H16D4FNO3S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Prasugrel-d4


Prasugrel-d4 is the deuterium labeled Prasugrel[1]. Prasugrel (PCR 4099), a thienopyridine and prodrug, inhibits platelet function. Prasugrel is an orally active and potent P2Y12 receptor antagonist, and inhibits ADP-induced platelet aggregation[2].

 Names

Name [5-[1-(2-fluorophenyl)-2-oxo-2-(2,2,3,3-tetradeuteriocyclopropyl)ethyl]-6,7-dihydro-4H-thieno[3,2-c]pyridin-2-yl] acetate
Synonym More Synonyms

 Prasugrel-d4 Biological Activity

Description Prasugrel-d4 is the deuterium labeled Prasugrel[1]. Prasugrel (PCR 4099), a thienopyridine and prodrug, inhibits platelet function. Prasugrel is an orally active and potent P2Y12 receptor antagonist, and inhibits ADP-induced platelet aggregation[2].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. Wijeyeratne YD, et al. Anti-platelet therapy: ADP receptor antagonists. Br J Clin Pharmacol. 2011 Oct;72(4):647-57.  

[3]. Sugidachi A, et al. The greater in vivo antiplatelet effects of prasugrel as compared to clopidogrel reflect more efficient generation of its active metabolite with similar antiplatelet activity to that of clopidogrel's active metabolite. J Thromb Haemost. 2007 Jul;5(7):1545-51.  

 Chemical & Physical Properties

Molecular Formula C20H16D4FNO3S
Molecular Weight 377.46600
Exact Mass 377.14000
PSA 74.85000
LogP 3.82890

 Synonyms

Prasugrel-d5
CS 747