(±)-Naproxen-13C,d3

Modify Date: 2024-01-28 14:37:23

(±)-Naproxen-13C,d3 Structure
(±)-Naproxen-13C,d3 structure
Common Name (±)-Naproxen-13C,d3
CAS Number 1261392-52-2 Molecular Weight 234.270
Density 1.2±0.1 g/cm3 Boiling Point N/A
Molecular Formula C1313CH11D3O3 Melting Point N/A
MSDS Chinese USA Flash Point N/A
Symbol GHS06
GHS06
Signal Word Danger

 Use of (±)-Naproxen-13C,d3


(±)-Naproxen-13C,d3 is the deuterium and 13C labeled (±)-Naproxen[1]. (±)-Naproxen ((Rac)-Naproxen) is a racemate of Naproxen (HY-15030). Naproxen is a COX-1 and COX-2 inhibitor with IC50s of 8.72 and 5.15 μM, respectively.

 Names

Name 2-{6-[(13C,2H3)Methyloxy]-2-naphthyl}propanoic acid
Synonym More Synonyms

 (±)-Naproxen-13C,d3 Biological Activity

Description (±)-Naproxen-13C,d3 is the deuterium and 13C labeled (±)-Naproxen[1]. (±)-Naproxen ((Rac)-Naproxen) is a racemate of Naproxen (HY-15030). Naproxen is a COX-1 and COX-2 inhibitor with IC50s of 8.72 and 5.15 μM, respectively.
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Molecular Formula C1313CH11D3O3
Molecular Weight 234.270
Exact Mass 234.116486
Index of Refraction 1.609

 Safety Information

Symbol GHS06
GHS06
Signal Word Danger
Hazard Statements H301
Precautionary Statements P301 + P310
RIDADR UN 2811 6.1 / PGIII

 Synonyms

2-Naphthaleneacetic acid, α-methyl-6-(methyl-13C-d3-oxy)-
2-{6-[(13C,2H3)Methyloxy]-2-naphthyl}propanoic acid