Toltrazuril sulfoxide-d3

Modify Date: 2024-01-14 20:17:56

Toltrazuril sulfoxide-d3 Structure
Toltrazuril sulfoxide-d3 structure
Common Name Toltrazuril sulfoxide-d3
CAS Number 1346603-43-7 Molecular Weight 444.40
Density N/A Boiling Point N/A
Molecular Formula C18H11D3F3N3O5S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Toltrazuril sulfoxide-d3


rac Toltrazuril-d3 Sulfoxide is the deuterium labeled Toltrazuril sulfoxide. Toltrazuril sulfoxide is a short-lived intermediary metabolite of Toltrazuril (HY-B0175), and then can be metabolized to the reactive toltrazuril sulfone (TZR-SO2) in vivo. Toltrazuril is an antiprotozoal agent that acts upon Coccidia parasites[1][2].

 Names

Name Toltrazuril sulfoxide-d3

 Toltrazuril sulfoxide-d3 Biological Activity

Description rac Toltrazuril-d3 Sulfoxide is the deuterium labeled Toltrazuril sulfoxide. Toltrazuril sulfoxide is a short-lived intermediary metabolite of Toltrazuril (HY-B0175), and then can be metabolized to the reactive toltrazuril sulfone (TZR-SO2) in vivo. Toltrazuril is an antiprotozoal agent that acts upon Coccidia parasites[1][2].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Jong-Hwan Lim, et al. Pharmacokinetics of toltrazuril and its metabolites, toltrazuril sulfoxide and toltrazuril sulfone, after a single oral administration to pigs. J Vet Med Sci. 2010 Aug;72(8):1085-7.

[3]. H Mehlhorn, et al. Toltrazuril effective against a broad spectrum of protozoan parasites. Parasitol Res. 1988;75(1):64-6.

 Chemical & Physical Properties

Molecular Formula C18H11D3F3N3O5S
Molecular Weight 444.40