Metallo-β-lactamase-IN-5

Modify Date: 2024-01-02 18:17:33

Metallo-β-lactamase-IN-5 Structure
Metallo-β-lactamase-IN-5 structure
Common Name Metallo-β-lactamase-IN-5
CAS Number 1417737-65-5 Molecular Weight 348.36
Density N/A Boiling Point N/A
Molecular Formula C19H16N4O3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Metallo-β-lactamase-IN-5


Metallo-β-lactamase-IN-5 (compound 5c) is a potent metallo-β-lactamases (MBL) inhibitor. Metallo-β-lactamase-IN-5 shows inhibitory activity against MBLs NDM-1 and VIM-1. Metallo-β-lactamase-IN-5 inhibits HUVECs with an IC50 of 45 μg/mL. Metallo-β-lactamase-IN-5 plus Imipenem exhibits synergistic antimicrobial activity[1].

 Names

Name Metallo-β-lactamase-IN-5

 Metallo-β-lactamase-IN-5 Biological Activity

Description Metallo-β-lactamase-IN-5 (compound 5c) is a potent metallo-β-lactamases (MBL) inhibitor. Metallo-β-lactamase-IN-5 shows inhibitory activity against MBLs NDM-1 and VIM-1. Metallo-β-lactamase-IN-5 inhibits HUVECs with an IC50 of 45 μg/mL. Metallo-β-lactamase-IN-5 plus Imipenem exhibits synergistic antimicrobial activity[1].
Related Catalog
References

[1]. Proschak A, Martinelli G, Frank D, Rotter MJ, Brunst S, Weizel L, Burgers LD, Fürst R, Proschak E, Sosič I, Gobec S, Wichelhaus TA. Nitroxoline and its derivatives are potent inhibitors of metallo-β-lactamases. Eur J Med Chem. 2022 Jan 15;228:113975.

 Chemical & Physical Properties

Molecular Formula C19H16N4O3
Molecular Weight 348.36