PBD dimer-2

Modify Date: 2024-01-21 19:12:20

PBD dimer-2 structure	Common Name	PBD dimer-2
	CAS Number	145325-57-1	Molecular Weight	560.64100
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃₁H₃₆N₄O₆	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of PBD dimer-2

PBD dimer-2 (compound 2c) is a C8-linked pyrrolobenzodiazepine dimer. PBD dimer-2 can span an extra base pair and cross-link the 5′-Pu-GA(T/A)TC-Py sequence. PBD dimer-2 can be used as a payload for antibody–drug conjugates (ADCs), and it can be used for the research of cancer[1][2].

Name	1,1'-<(pentane-1,5-diyl)dioxy>bis<(11aS)-7-methoxy-1,2,3,11a-tetrahydro-5H-pyrrolo<1,2-c><1,4>benzodiazepin-5-one>
Synonym	More Synonyms

Description	PBD dimer-2 (compound 2c) is a C8-linked pyrrolobenzodiazepine dimer. PBD dimer-2 can span an extra base pair and cross-link the 5′-Pu-GA(T/A)TC-Py sequence. PBD dimer-2 can be used as a payload for antibody–drug conjugates (ADCs), and it can be used for the research of cancer[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
References	[1]. Smellie M, et al. Sequence-selective recognition of duplex DNA through covalent interstrand cross-linking: kinetic and molecular modeling studies with pyrrolobenzodiazepine dimers. Biochemistry. 2003 Jul 15;42(27):8232-9. [2]. Staben LR, et al. Systematic Variation of Pyrrolobenzodiazepine (PBD)-Dimer Payload Physicochemical Properties Impacts Efficacy and Tolerability of the Corresponding Antibody-Drug Conjugates. J Med Chem. 2020 Sep 10;63(17):9603-9622.

Description

Related Catalog

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

References

[1]. Smellie M, et al. Sequence-selective recognition of duplex DNA through covalent interstrand cross-linking: kinetic and molecular modeling studies with pyrrolobenzodiazepine dimers. Biochemistry. 2003 Jul 15;42(27):8232-9.

[2]. Staben LR, et al. Systematic Variation of Pyrrolobenzodiazepine (PBD)-Dimer Payload Physicochemical Properties Impacts Efficacy and Tolerability of the Corresponding Antibody-Drug Conjugates. J Med Chem. 2020 Sep 10;63(17):9603-9622.

Molecular Formula	C₃₁H₃₆N₄O₆
Molecular Weight	560.64100
Exact Mass	560.26300
PSA	102.26000
LogP	3.71990

1,1-[(pentane-1,5-diyl)dioxy]bis[(11aS)-7-methoxy-1,2,3,11a-tetrahydro-5H-pyrrolo[2,1-c][1,4] benzodiazepine-5-one]

1,1'-[(pentane-1,5-diyl)dioxy]bis[(11aS)-7-methoxy-1,2,3,11a-tetrahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepine-5-one]

1,1'-[(pentane-1,5-diyl)dioxy]bis[(11aS)-7-methoxy-1,2,3,11a-tetrahydro-5H-pyrrolo[1,2-c][1,4]benzodiazepin-5-one]

PBD dimer-2

Use of PBD dimer-2

Names

PBD dimer-2 Biological Activity

Chemical & Physical Properties

Synonyms