Plm IV inhibitor-2

Modify Date: 2024-01-27 10:56:01

Plm IV inhibitor-2 Structure
Plm IV inhibitor-2 structure
Common Name Plm IV inhibitor-2
CAS Number 1539276-38-4 Molecular Weight 642.87
Density N/A Boiling Point N/A
Molecular Formula C39H54N4O4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Plm IV inhibitor-2


Plm IV inhibitor-2 (compound 3) is a potent digestive vacuole plasmepsins IV (Plm IV) inhibitor with IC50 values of 24 nM, 70 nM and 0.3 μM for Plm IV, II and I, respectively. Plm IV inhibitor-2 can be used to research malaria caused by Plasmodium parasites[1].

 Names

Name Plm IV inhibitor-2

 Plm IV inhibitor-2 Biological Activity

Description Plm IV inhibitor-2 (compound 3) is a potent digestive vacuole plasmepsins IV (Plm IV) inhibitor with IC50 values of 24 nM, 70 nM and 0.3 μM for Plm IV, II and I, respectively. Plm IV inhibitor-2 can be used to research malaria caused by Plasmodium parasites[1].
Related Catalog
Target

Plm IV:24 nM (IC50)

Plm II:70 nM (IC50)

Plm I:0.3 μM (IC50)

References

[1]. Jaudzems K, et al. Plasmepsin inhibitory activity and structure-guided optimization of a potent hydroxyethylamine-based antimalarial hit. ACS Med Chem Lett. 2014 Jan 13;5(4):373-7.

 Chemical & Physical Properties

Molecular Formula C39H54N4O4
Molecular Weight 642.87