2412144-74-0
2412144-74-0 structure
- Name: Aurora A inhibitor 2
- Chemical Name: Aurora A inhibitor 2
- CAS Number: 2412144-74-0
- Molecular Formula: C24H26N6O3
- Molecular Weight: 446.50
- Catalog: Signaling Pathways Apoptosis Apoptosis
- Create Date: 2022-06-30 19:05:16
- Modify Date: 2024-01-12 14:37:22
-
Aurora A inhibitor 2 (Compound 16h) is a potent Aurora A kinase inhibitor with an IC50 of 21.94 nM. Aurora A inhibitor 2 induces caspase-dependent apoptosis in MDA-MB-231 cells[1].
| Name | Aurora A inhibitor 2 |
|---|
| Description | Aurora A inhibitor 2 (Compound 16h) is a potent Aurora A kinase inhibitor with an IC50 of 21.94 nM. Aurora A inhibitor 2 induces caspase-dependent apoptosis in MDA-MB-231 cells[1]. |
|---|---|
| Related Catalog | |
| Target |
Aurora A:21.94 nM (IC50) Aurora B:273.18 nM (IC50) |
| In Vitro | Aurora A inhibitor 2 (Compound 16h) (0-20 µM, 48 h) shows potent antiproliferative activity against various human cancer cells, and inhibits colony formation[1]. Aurora A inhibitor 2 (0-4 µM, 24 h) inhibits the expression of phosphorylation of Aurora A and Histone H3 in a dose-dependent manner, and induces G2/M cell cycle arrest [1]. Aurora A inhibitor 2 (0-4 µM, 48 h) induces obvious apoptosis in MDA-MB-231 cells in a concentration-dependent manner[1]. Cell Cytotoxicity Assay[1] Cell Line: Breast cancer MDA-MB231, prostate cancer PC3, and neuroblastoma SH-SY5Y cells Concentration: 0-20 µM Incubation Time: 48 h Result: Displayed potent antiproliferative activity with IC50 values of 0.38 ± 0.08, 1.09 ± 0.24, and 0.77 ± 0.12 µM against MDA-MB-231, PC3, and SH-SY5Y cells. Western Blot Analysis[1] Cell Line: MDAMB-231 Concentration: 1, 2, and 4 µM Incubation Time: 24 h Result: A dose-dependent and significant reduction in the phosphorylation of Aurora A and Histone H3 was observed. Significantly increased the levels of cleaved caspase 3/9 and cleaved-PARP. Cell Cycle Analysis[1] Cell Line: MDAMB-231 Concentration: 1, 2, and 4 µM Incubation Time: 24 h Result: Dose-dependently increased the and population of cells in the G2/M phase. Apoptosis Analysis[1] Cell Line: MDAMB-231 Concentration: 1, 2, and 4 µM Incubation Time: 48 h Result: Induced obvious apoptosis in a concentration-dependent manner. |
| References |
| Molecular Formula | C24H26N6O3 |
|---|---|
| Molecular Weight | 446.50 |