Suberic acid-d12

Modify Date: 2024-01-06 17:58:29

Suberic acid-d12 Structure
Suberic acid-d12 structure
Common Name Suberic acid-d12
CAS Number 169397-99-3 Molecular Weight 186.26800
Density N/A Boiling Point N/A
Molecular Formula C8H2D12O4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Suberic acid-d12


Suberic acid-d12 is the deuterium labeled Suberic acid[1]. Suberic acid (Octanedioic acid) is found to be associated with carnitine-acylcarnitine translocase deficiency, malonyl-Coa decarboxylase deficiency[2].

 Names

Name 1,8-octanedioic-d12 acid

 Suberic acid-d12 Biological Activity

Description Suberic acid-d12 is the deuterium labeled Suberic acid[1]. Suberic acid (Octanedioic acid) is found to be associated with carnitine-acylcarnitine translocase deficiency, malonyl-Coa decarboxylase deficiency[2].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. Gregersen N, et al. General (medium-chain) acyl-CoA dehydrogenase deficiency (non-ketotic dicarboxylic aciduria): quantitative urinary excretion pattern of 23 biologically significant organic acids in three cases. Clin Chim Acta. 1983 Aug 15;132(2):181-91.  

 Chemical & Physical Properties

Molecular Formula C8H2D12O4
Molecular Weight 186.26800
Exact Mass 186.16500
PSA 74.60000
LogP 1.49620