FR181157

Modify Date: 2024-01-24 00:58:13

Use of FR181157

FR181157, an orally active PGI2 agonist activity with especially good pharmacokinetic properties[1].

Name	sodium,2-[3-[[(1S)-2-(4,5-diphenyl-1,3-oxazol-2-yl)cyclohex-2-en-1-yl]methyl]phenoxy]acetate
Synonym	More Synonyms

Description	FR181157, an orally active PGI2 agonist activity with especially good pharmacokinetic properties[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Prostaglandin Receptor Research Areas >> Inflammation/Immunology
In Vitro	FR181157 exhibits high binding affinity for the IP receptor with a Ki of 54 nM and anti-aggregative potency with an IC50 of 60 nM[1].
References	[1]. Kouji Hattori , et al. A simple stereoselective synthesis and biological evaluation of FR181157: orally active prostacyclin mimetic. Bioorg Med Chem Lett. 2003 Dec 15;13(24):4277-9.

Acetic acid,(3-((2-(4,5-diphenyl-2-oxazolyl)-2-cyclohexen-1-yl)methyl)phenoxy)-,sodium salt,(S)

Acetic acid,(3-(((1S)-2-(4,5-diphenyl-2-oxazolyl)-2-cyclohexen-1-yl)methyl)phenoxy)-,sodium salt