DACN(Tos2,6-OH)

Modify Date: 2024-07-18 07:38:17

DACN(Tos2,6-OH) Structure
DACN(Tos2,6-OH) structure
Common Name DACN(Tos2,6-OH)
CAS Number 2109751-74-6 Molecular Weight 448.56
Density N/A Boiling Point N/A
Molecular Formula C21H24N2O5S2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of DACN(Tos2,6-OH)


DACN(Tos2,6-OH) is a click chemistry reagent containing an Azide. The alkyne moiety within the ring has a unique bent structure and high reactivity toward cycloaddition reactions. The reactivity of an alkyne heavily depends on the electronic and steric characteristics of the substituents as well as structural strain. In comparison to nonbent acyclic alkynes, cyclononyne alkynes show remarkably high reactivity. Such strain-promoted azide-alkyne cycloadditions (SPAAC) using cycloalkynes have served for reliable molecular conjugation in a broad range of fields. The nitrogens are used as connection points for a variety of functional units. In comparison to cyclooctynes, DACNs possess high thermal and chemical stability along with comparable click reactivity[1].

 Names

Name DACN(Tos2,6-OH)

 DACN(Tos2,6-OH) Biological Activity

Description DACN(Tos2,6-OH) is a click chemistry reagent containing an Azide. The alkyne moiety within the ring has a unique bent structure and high reactivity toward cycloaddition reactions. The reactivity of an alkyne heavily depends on the electronic and steric characteristics of the substituents as well as structural strain. In comparison to nonbent acyclic alkynes, cyclononyne alkynes show remarkably high reactivity. Such strain-promoted azide-alkyne cycloadditions (SPAAC) using cycloalkynes have served for reliable molecular conjugation in a broad range of fields. The nitrogens are used as connection points for a variety of functional units. In comparison to cyclooctynes, DACNs possess high thermal and chemical stability along with comparable click reactivity[1].
Related Catalog
References

[1]. Kazunobu Igawa, et al. Thieme Chemistry Journals Awardees: Where Are They Now? One-Pot Synthesis of Versatile Buckle Units for Click Chemistry: 4,8-Diazacyclononynes (DACNs). Synlett 2017; 28(16): 2110-2114.

 Chemical & Physical Properties

Molecular Formula C21H24N2O5S2
Molecular Weight 448.56