Antitubercular agent-27

Modify Date: 2024-01-10 18:20:24

Antitubercular agent-27 structure	Common Name	Antitubercular agent-27
	CAS Number	2460651-09-4	Molecular Weight	346.14
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₄H₈BrN₃O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Antitubercular agent-27

Antitubercular agent-27 (compound 1) is a potent antitubercular agent with an IC50 value of 3.2 µM, an MIC value of 7.8 µM, an IC90 value of 7.0 µM. Antitubercular agent-27 shows antimycobacterial activity for resistant isolates of Mycobacterium tuberculosis H37Rv. Antitubercular agent-27 shows effective intracellular antimycobacterial activity and low cytotoxicity[1].

Name	Antitubercular agent-27

Description	Antitubercular agent-27 (compound 1) is a potent antitubercular agent with an IC50 value of 3.2 µM, an MIC value of 7.8 µM, an IC90 value of 7.0 µM. Antitubercular agent-27 shows antimycobacterial activity for resistant isolates of Mycobacterium tuberculosis H37Rv. Antitubercular agent-27 shows effective intracellular antimycobacterial activity and low cytotoxicity[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
In Vitro	Antitubercular agent-27 (compound 1) shows antimycobacterial activity for resistant isolates of M. tuberculosis H37Rv with IC50s of 2.4, 100, 120, 1.3, 3.1 µM, MICs of 3.2, 140, 160, 2.4, 4.2 µM, IC90s of 3.0, 120, 142, 2.2, 3.5 µM for FQ-R1, INH-R1, INH-R2, RIF-R1, RIF-R2, respectively[1]. Antitubercular agent-27 (0-200 µM) shows antibacterial activity with an MIC value of 0.80 µM, IC50 value of 0.23 µM, and IC90 value of 0.43 µM in low oxygen condition, and an MIC value of 0.45 µM, IC50 value of 0.27 µM, and IC90 value of 0.35 µM in normal oxygen condition[1]. Antitubercular agent-27 (0-200 µM) shows intracellular activity with an IC50 value of 1.45 µM, and IC90 value of 1.61 µM, and low cytotoxicity with an IC50 value of >100 µM[1].
References	[1]. Patel H, et al. Synthesis and in vitro antitubercular activity of pyridine analouges against the resistant Mycobacterium tuberculosis. Bioorg Chem. 2020 Sep;102:104099.

Molecular Formula	C₁₄H₈BrN₃O₃
Molecular Weight	346.14

Antitubercular agent-27

Use of Antitubercular agent-27

Names

Antitubercular agent-27 Biological Activity

Chemical & Physical Properties