CBP/p300-IN-19 hydrochloride
Modify Date: 2024-01-12 23:02:44
CBP/p300-IN-19 hydrochloride structure
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Common Name | CBP/p300-IN-19 hydrochloride | ||
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| CAS Number | 2592638-14-5 | Molecular Weight | 514.01 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C30H28ClN3O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of CBP/p300-IN-19 hydrochlorideCBP/p300-IN-19 hydrochloride is a potent and selective p300/CBP HAT inhibitor with IC50s of 1.4, 2.2, >100, >100 µM for p300-HAT, CBP-HAT, PCAF, Myst3, respectively. CBP/p300-IN-19 hydrochloride shows antitumor activity[1]. |
| Name | CBP/p300-IN-19 hydrochloride |
|---|
| Description | CBP/p300-IN-19 hydrochloride is a potent and selective p300/CBP HAT inhibitor with IC50s of 1.4, 2.2, >100, >100 µM for p300-HAT, CBP-HAT, PCAF, Myst3, respectively. CBP/p300-IN-19 hydrochloride shows antitumor activity[1]. |
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| Related Catalog | |
| Target |
p300:1.4 μM (IC50) PCAF:2.2 μM (IC50) CBP:>100 μM (IC50) Myst3:>100 μM (IC50) |
| In Vitro | CBP/p300-IN-19 hydrochloride (compound 29) shows antiproliferative activity with EC50s of 5.3, 8.5, 6.2, 4.4, 1.2, 4.3, 3.6, 8.7, 6.4 µM for MCF-7, MDA-MB231, LNCaP, PC-3, PANC-1, MDA-PANC-28, Molm-13, MV4;11, RPMI-8226 cells, respectively[1]. CBP/p300-IN-19 hydrochloride (0, 5, 10 µM; 12 h) dose-dependenly inhibits the acetylation of H3K18, H3K9 and K27[1]. Western Blot Analysis[1] Cell Line: Kasumi-1 leukemia cells Concentration: 0, 5, 10 µM Incubation Time: 12 h Result: Dose-dependently inhibited the acetylation of H3K18, H3K9 and K27. |
| References |
| Molecular Formula | C30H28ClN3O3 |
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| Molecular Weight | 514.01 |