FGFR-IN-8

Modify Date: 2024-04-06 16:31:17

FGFR-IN-8 structure	Common Name	FGFR-IN-8
	CAS Number	2640217-64-5	Molecular Weight	584.50
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₇H₃₁Cl₂N₉O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of FGFR-IN-8

FGFR-IN-8 (Compound 17a) is a highly potent and orally active panFGFR inhibitor against wild-type and mutant FGFRs. FGFR-IN-8 shows inhibition with IC50 values of <0.5, 189.1, <0.5, 22.6, <0.5 and 7.30 nM against FGFR1, V564F-FGFR2, N549H-FGFR2, V555M-FGFR3, FGFR3 and FGFR4, respectively. GFR-IN-8 induces cancer cell apoptosis and shows anticancer activities[1].

Name	FGFR-IN-8

Description	FGFR-IN-8 (Compound 17a) is a highly potent and orally active panFGFR inhibitor against wild-type and mutant FGFRs. FGFR-IN-8 shows inhibition with IC50 values of <0.5, 189.1, <0.5, 22.6, <0.5 and 7.30 nM against FGFR1, V564F-FGFR2, N549H-FGFR2, V555M-FGFR3, FGFR3 and FGFR4, respectively. GFR-IN-8 induces cancer cell apoptosis and shows anticancer activities[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> FGFR
Target	FGFR1:<0.5 nM (IC50) V564F-FGFR2:189.1 nM (IC50) N549H-FGFR2:<0.5 nM (IC50) V555M-FGFR3:22.6 nM (IC50) FGFR3:<0.5 nM (IC50) FGFR4:7.30 nM (IC50) V561M-FGFR1:262.5 nM (IC50) K650E-FGFR3:<0.5 nM (IC50) K650M-FGFR3:4.8 nM (IC50)
References	[1]. Ryu S, et al. Identification of Pyridinyltriazine Derivatives as Potent panFGFR Inhibitors against Gatekeeper Mutants for Overcoming Drug Resistance. J Med Chem. 2022 Apr 28;65(8):6017-6038.

Molecular Formula	C₂₇H₃₁Cl₂N₉O₂
Molecular Weight	584.50

FGFR-IN-8

Use of FGFR-IN-8

Names

FGFR-IN-8 Biological Activity

Chemical & Physical Properties