Bcl-2-IN-5

Modify Date: 2024-04-03 07:37:32

Bcl-2-IN-5 structure	Common Name	Bcl-2-IN-5
	CAS Number	2728752-20-1	Molecular Weight	1015.20
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₅₅H₆₃FN₈O₈S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Bcl-2-IN-5

Bcl-2-IN-5 is a BCL-2 inhibitor with IC50s of 0.12 nM, 0.14 nM and 0.22 nM for Bcl-2 wild type, Bcl-2 D103Y and Bcl-2 G101V, respectively. Bcl-2-IN-5 inhibits the cell growth with IC50 values of 0.2 nM and 0.44 nM for Bcl 2-G101V knock-in RS4; 11 and RS4; 11 cells, respectively (WO2021208963A1; Example 155)[1].

Name	Bcl-2-IN-5

Description	Bcl-2-IN-5 is a BCL-2 inhibitor with IC50s of 0.12 nM, 0.14 nM and 0.22 nM for Bcl-2 wild type, Bcl-2 D103Y and Bcl-2 G101V, respectively. Bcl-2-IN-5 inhibits the cell growth with IC50 values of 0.2 nM and 0.44 nM for Bcl 2-G101V knock-in RS4; 11 and RS4; 11 cells, respectively (WO2021208963A1; Example 155)[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Bcl-2 Family Research Areas >> Cancer
Target	Bcl-2:0.12 nM (IC50) Bcl-2 D103Y:0.14 nM (IC50) Bcl-2 G101V:0.22 nM (IC50)
References	[1]. Hai Xue, et al. Bcl-2 inhibitor. WO2021208963A1.

Molecular Formula	C₅₅H₆₃FN₈O₈S
Molecular Weight	1015.20

Bcl-2-IN-5

Use of Bcl-2-IN-5

Names

Bcl-2-IN-5 Biological Activity

Chemical & Physical Properties