Thrombin inhibitor 7

Modify Date: 2024-04-06 12:53:17

Thrombin inhibitor 7 structure	Common Name	Thrombin inhibitor 7
	CAS Number	2866508-00-9	Molecular Weight	465.51
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₆H₂₃N₇O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Thrombin inhibitor 7

Thrombin inhibitor 7 is a potent FXIIa inhibitor with IC50 values of 28 nM, >132 µM for FXIIa and FXIa, respectively. Thrombin inhibitor 7 shows low cytotoxicity[1].

Name	Thrombin inhibitor 7

Description	Thrombin inhibitor 7 is a potent FXIIa inhibitor with IC50 values of 28 nM, >132 µM for FXIIa and FXIa, respectively. Thrombin inhibitor 7 shows low cytotoxicity[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease
In Vitro	Thrombin inhibitor 7 (compound 33b) (0-300 µM; 24 h) shows low cytotoxicity in HepG2, A549 cells[1]. Cell Cytotoxicity Assay[1] Cell Line: HepG2, A549 cells Concentration: 0-300 µM Incubation Time: 24 h Result: Showed low cytotoxicity in HepG2, A549 cells.
References	[1]. Imberg L, et al. Amide-functionalized 1,2,4-Triazol-5-amines as Covalent Inhibitors of Blood Coagulation Factor XIIa and Thrombin. ACS Pharmacol Transl Sci. 2022 Nov 30;5(12):1318-1347.

Molecular Formula	C₂₆H₂₃N₇O₂
Molecular Weight	465.51