UCK2 Inhibitor-2

Modify Date: 2024-04-03 06:29:21

UCK2 Inhibitor-2 structure	Common Name	UCK2 Inhibitor-2
	CAS Number	866842-71-9	Molecular Weight	497.56
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₈H₂₃N₃O₄S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of UCK2 Inhibitor-2

UCK2 Inhibitor-2 is a non-competitive uridine-cytidine kinase 2 (UCK2) inhibitor with an IC50 value of 3.8 µM. UCK2 Inhibitor-2 can suppress uridine salvage in cells[1].

Name	UCK2 Inhibitor-2

Description	UCK2 Inhibitor-2 is a non-competitive uridine-cytidine kinase 2 (UCK2) inhibitor with an IC50 value of 3.8 µM. UCK2 Inhibitor-2 can suppress uridine salvage in cells[1].
Related Catalog	Research Areas >> Cancer
Target	IC50: 3.8 µM (UCK2)[1]
In Vitro	UCK2 Inhibitor-2 (compound 20874830) 在浓度为 50 µM 时对 K562 细胞中的尿苷补救有 52% 的抑制作用。DHODH 的抑制增加了尿苷的回收，而 UCK2 抑制剂 UCK2 Inhibitor-2 (compound 20874830) 可以抑制这种增加[1]。
References	[1]. Ayse Okesli-Armlovich, et al. Discovery of small molecule inhibitors of human uridine-cytidine kinase 2 by high-throughput screening. Bioorg Med Chem Lett. 2019 Sep 15;29(18):2559-2564.

Molecular Formula	C₂₈H₂₃N₃O₄S
Molecular Weight	497.56