2376687-49-7
2376687-49-7 structure
- Name: UCK2 Inhibitor-3
- Chemical Name: UCK2 Inhibitor-3
- CAS Number: 2376687-49-7
- Molecular Formula: C19H13BrFN5O2S
- Molecular Weight: 474.31
- Catalog: Signaling Pathways Cell Cycle/DNA Damage DNA/RNA Synthesis
- Create Date: 2023-01-13 23:44:27
- Modify Date: 2024-09-10 19:17:50
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UCK2 Inhibitor-3 is a non-competitive inhibitor of uridine-cytidine kinase 2 (UCK2, a pyrimidine salvage enzyme) with an IC50 value of 16.6 μM. UCK2 can replace dihydroorotate dehydrogenase (DHODH), in a certain extent, in infected or rapidly dividing cells to continue efficient uridine salvage. UCK2 Inhibitor-3 also inhibits DNA polymerase eta and kappa with IC50s of 56 μM and 16 μM[1].
| Name | UCK2 Inhibitor-3 |
|---|
| Description | UCK2 Inhibitor-3 is a non-competitive inhibitor of uridine-cytidine kinase 2 (UCK2, a pyrimidine salvage enzyme) with an IC50 value of 16.6 μM. UCK2 can replace dihydroorotate dehydrogenase (DHODH), in a certain extent, in infected or rapidly dividing cells to continue efficient uridine salvage. UCK2 Inhibitor-3 also inhibits DNA polymerase eta and kappa with IC50s of 56 μM and 16 μM[1]. |
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| Related Catalog | |
| Target |
IC50: 16.6 μM (UCK2); 56 μM (DNA polymerase η); 16 μM (DNA polymerase κ)[1] |
| In Vitro | Dihydroorotate dehydrogenase (DHODH), a rate-limiting enzyme in mammalian de novo pyrimidine synthesis. UCK2 can make up for DHODH in a certain extent, in infected or rapidly dividing cells for uridine salvage. DHODH inhibition has antiviral and anticancer significance, while UCK2 Inhibitor-3 suppress nucleoside salvage in cells both in the presence and absence of DHODH inhibitors[1]. UCK2 Inhibitor-3 (compound 135416439) is an inhibitor against pyrimidine salvage enzyme, non-competitive with Uridine and ATP with Ki values of 13 μM and 12 μM, respectively[1]. UCK2 Inhibitor-3 (50 μM) inhibits UCK2 with inhibition rate of 31.3%[1]. |
| References |
| Molecular Formula | C19H13BrFN5O2S |
|---|---|
| Molecular Weight | 474.31 |