PI3Kδ-IN-15

Modify Date: 2024-01-19 19:14:30

PI3Kδ-IN-15 structure	Common Name	PI3Kδ-IN-15
	CAS Number	870281-17-7	Molecular Weight	401.40
	Density	1.5±0.1 g/cm3	Boiling Point	N/A
	Molecular Formula	C₂₁H₁₆FN₇O	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of PI3Kδ-IN-15

PI3Kδ-IN-15 (compound 6b) is a selective PI3Kδ inhibitor with an IC50 of 0.5 nM for p110δ. PI3Kδ-IN-15 inhibits PI3Kδ with >30-fold higher potency than PI3Kγ, PI3Kβ, and PI3Kα[1].

Name	5-Fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)ethyl]-4(3H)-quinazolinone
Synonym	More Synonyms

Description	PI3Kδ-IN-15 (compound 6b) is a selective PI3Kδ inhibitor with an IC50 of 0.5 nM for p110δ. PI3Kδ-IN-15 inhibits PI3Kδ with >30-fold higher potency than PI3Kγ, PI3Kβ, and PI3Kα[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PI3K/Akt/mTOR >> PI3K
Target	p110δ:0.5 nM (IC50) p110γ:15.3 nM (IC50) p110β:145 nM (IC50) p110α:152 nM (IC50)
References	[1]. Yeon Su Kim, et al. Synthesis and biological evaluation of novel purinyl quinazolinone derivatives as PI3Kδ-specific inhibitors for the treatment of hematologic malignancies. Bioorg Med Chem. 2021 Sep 1;45:116312.

Density	1.5±0.1 g/cm3
Molecular Formula	C₂₁H₁₆FN₇O
Molecular Weight	401.40
Exact Mass	401.140045
LogP	2.43
Index of Refraction	1.759

4(3H)-Quinazolinone, 5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)ethyl]-

5-Fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)ethyl]-4(3H)-quinazolinone

PI3Kδ-IN-15

Use of PI3Kδ-IN-15

Names

PI3Kδ-IN-15 Biological Activity

Chemical & Physical Properties

Synonyms