l-leucine-2-d1

Modify Date: 2024-01-09 16:18:51

l-leucine-2-d1 structure	Common Name	l-leucine-2-d1
	CAS Number	89836-93-1	Molecular Weight	132.17900
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₆H₁₂DNO₂	Melting Point	>300 °C(lit.)
	MSDS	Chinese	Flash Point	N/A

Use of l-leucine-2-d1

L-Leucine-d1 is the deuterium labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway[1].

Name	l-leucine-2-d1
Synonym	More Synonyms

Description	L-Leucine-d1 is the deuterium labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway[1].
Related Catalog	Signaling Pathways >> PI3K/Akt/mTOR >> mTOR Research Areas >> Metabolic Disease
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Rachdi L, et al. L-leucine alters pancreatic β-cell differentiation and function via the mTor signaling pathway. Diabetes. 2012 Feb;61(2):409-17. [3]. Baoshan Xu, et al. Stimulation of mTORC1 with L-leucine rescues defects associated with Roberts syndrome. PLoS Genet. 2013;9(10):e1003857. [4]. Rachdi L, et al. L-leucine alters pancreatic β-cell differentiation and function via the mTor signaling pathway. Diabetes. 2012 Feb;61(2):409-17. [5]. Rachdi L, et al. L-leucine alters pancreatic β-cell differentiation and function via the mTor signaling pathway. Diabetes. 2012 Feb;61(2):409-17. [6]. Rachdi L, et al. L-leucine alters pancreatic β-cell differentiation and function via the mTor signaling pathway. Diabetes. 2012 Feb;61(2):409-17. [7]. Rachdi L, et al. L-leucine alters pancreatic β-cell differentiation and function via the mTor signaling pathway. Diabetes. 2012 Feb;61(2):409-17. [8]. Rachdi L, et al. L-leucine alters pancreatic β-cell differentiation and function via the mTor signaling pathway. Diabetes. 2012 Feb;61(2):409-17. [9]. Rachdi L, et al. L-leucine alters pancreatic β-cell differentiation and function via the mTor signaling pathway. Diabetes. 2012 Feb;61(2):409-17. [10]. Rachdi L, et al. L-leucine alters pancreatic β-cell differentiation and function via the mTor signaling pathway. Diabetes. 2012 Feb;61(2):409-17. [11]. Bruckbauer A, et al. Synergistic effects of leucine and resveratrol on insulin sensitivity and fat metabolism in adipocytes and mice. Nutr Metab (Lond). 2012 Aug 22;9(1):77. [12]. Baoshan Xu, et al. Stimulation of mTORC1 with L-leucine rescues defects associated with Roberts syndrome. PLoS Genet. 2013;9(10):e1003857. [13]. Baoshan Xu, et al. Stimulation of mTORC1 with L-leucine rescues defects associated with Roberts syndrome. PLoS Genet. 2013;9(10):e1003857. [14]. Baoshan Xu, et al. Stimulation of mTORC1 with L-leucine rescues defects associated with Roberts syndrome. PLoS Genet. 2013;9(10):e1003857. [15]. Baoshan Xu, et al. Stimulation of mTORC1 with L-leucine rescues defects associated with Roberts syndrome. PLoS Genet. 2013;9(10):e1003857. [16]. Baoshan Xu, et al. Stimulation of mTORC1 with L-leucine rescues defects associated with Roberts syndrome. PLoS Genet. 2013;9(10):e1003857. [17]. Baoshan Xu, et al. Stimulation of mTORC1 with L-leucine rescues defects associated with Roberts syndrome. PLoS Genet. 2013;9(10):e1003857. [18]. Baoshan Xu, et al. Stimulation of mTORC1 with L-leucine rescues defects associated with Roberts syndrome. PLoS Genet. 2013;9(10):e1003857. [19]. Bruckbauer A, et al. Synergistic effects of leucine and resveratrol on insulin sensitivity and fat metabolism in adipocytes and mice. Nutr Metab (Lond). 2012 Aug 22;9(1):77. [20]. Bruckbauer A, et al. Synergistic effects of leucine and resveratrol on insulin sensitivity and fat metabolism in adipocytes and mice. Nutr Metab (Lond). 2012 Aug 22;9(1):77. [21]. Bruckbauer A, et al. Synergistic effects of leucine and resveratrol on insulin sensitivity and fat metabolism in adipocytes and mice. Nutr Metab (Lond). 2012 Aug 22;9(1):77. [22]. Bruckbauer A, et al. Synergistic effects of leucine and resveratrol on insulin sensitivity and fat metabolism in adipocytes and mice. Nutr Metab (Lond). 2012 Aug 22;9(1):77. [23]. Bruckbauer A, et al. Synergistic effects of leucine and resveratrol on insulin sensitivity and fat metabolism in adipocytes and mice. Nutr Metab (Lond). 2012 Aug 22;9(1):77. [24]. Bruckbauer A, et al. Synergistic effects of leucine and resveratrol on insulin sensitivity and fat metabolism in adipocytes and mice. Nutr Metab (Lond). 2012 Aug 22;9(1):77. [25]. Bruckbauer A, et al. Synergistic effects of leucine and resveratrol on insulin sensitivity and fat metabolism in adipocytes and mice. Nutr Metab (Lond). 2012 Aug 22;9(1):77.

Melting Point	>300 °C(lit.)
Molecular Formula	C₆H₁₂DNO₂
Molecular Weight	132.17900
Exact Mass	132.10100
PSA	63.32000
LogP	1.14470

(S)-Z-2-[2H1]-Leu

CAS#:57224-92-7

~86%

l-leucine-2-d1

CAS#:89836-93-1

Literature: Mitulovi, Goran; Laemmerhofer, Michael; Maier; Lindner, Wolfgang Journal of Labelled Compounds and Radiopharmaceuticals, 2000 , vol. 43, # 5 p. 449 - 461

L-leucine

CAS#:61-90-5

~62%

l-leucine-2-d1

CAS#:89836-93-1

Literature: Faleev, N. G.; Ruvinov, S. B.; Saporovskaya, M. B.; Belikov, V. M.; Zakomyrdina, L. N.; et al. Tetrahedron Letters, 1990 , vol. 31, # 48 p. 7051 - 7054

dl-leucine-2-d1

CAS#:282726-23-2

l-leucine-2-d1

CAS#:89836-93-1

Literature: Journal of Labelled Compounds and Radiopharmaceuticals, , vol. 43, # 5 p. 449 - 461

Sodium 4-methyl...

CAS#:4502-00-5

D-LEUCINE-2-D

CAS#:89836-92-0

l-leucine-2-d1

CAS#:89836-93-1

Literature: Bulletin of the Chemical Society of Japan, , vol. 56, # 12 p. 3652 - 3656

L-leucine

CAS#:61-90-5

D-LEUCINE-2-D

CAS#:89836-92-0

l-leucine-2-d1

CAS#:89836-93-1

Literature: Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), , vol. 38, # 10 p. 2154 - 2156 Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, , # 10 p. 2341 - 2343

ethyl benzoyl-L...

CAS#:1255087-82-1

l-leucine-2-d1

CAS#:89836-93-1

Literature: Organic and Biomolecular Chemistry, , vol. 9, # 23 p. 7983 - 7985

Precursor 5
CAS#:57224-92-7 (S)-Z-2-[2H1]-Leu CAS#:61-90-5 L-leucine CAS#:282726-23-2 dl-leucine-2-d1 CAS#:4502-00-5 Sodium 4-methyl...
CAS#:1255087-82-1 ethyl benzoyl-L...
DownStream 0

homoserine lactone*HBr

(S)-2-[2H1]-Leu

L-homoserine lactone hydrobromide

(S)-2-amino-2-deuterio-4-methyl-pentanoic acid

L-homoserine lactone HBr

(S)-3-Aminodihydrofuran-2(3H)-one hydrobromide

l-leucine-2-d1

Use of l-leucine-2-d1

Names

l-leucine-2-d1 Biological Activity

Chemical & Physical Properties

Synthetic Route

Precursor & DownStream

Synonyms