替卡西林
替卡西林结构式
|
常用名 | 替卡西林 | 英文名 | Ticarcillin |
|---|---|---|---|---|
| CAS号 | 34787-01-4 | 分子量 | 384.427 | |
| 密度 | 1.6±0.1 g/cm3 | 沸点 | 768.3±60.0 °C at 760 mmHg | |
| 分子式 | C15H16N2O6S2 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | 418.4±32.9 °C | |
| 符号 |
GHS08 |
信号词 | Danger |
替卡西林用途替卡西林是一种半合成、广谱、羧青霉素抗菌剂,对革兰氏阳性球菌(包括链球菌和葡萄球菌)具有活性。替卡西林对大多数革兰氏阴性菌也有效,包括铜绿假单胞菌。替卡西林可用于下呼吸道感染、皮肤和皮肤结构感染、尿路感染和腹腔内感染研究[1][2][3]。 |
| 中文名 | 替卡西林添加剂 |
|---|---|
| 英文名 | ticarcillin |
| 中文别名 | 替卡西林 |
| 英文别名 | 更多 |
| 描述 | 替卡西林是一种半合成、广谱、羧青霉素抗菌剂,对革兰氏阳性球菌(包括链球菌和葡萄球菌)具有活性。替卡西林对大多数革兰氏阴性菌也有效,包括铜绿假单胞菌。替卡西林可用于下呼吸道感染、皮肤和皮肤结构感染、尿路感染和腹腔内感染研究[1][2][3]。 |
|---|---|
| 相关类别 | |
| 体外研究 | 替卡西林处理(10mg/L；18h)显示出抗菌活性[1]。细胞活力测定[2]细胞系：铜绿假单胞菌浓度：10 mg/L孵育时间：18小时结果：替卡西林对菌株的MIC在6.3-12.5 mg/L之间。 |
| 体内研究 |
替卡西林(皮下注射；50、100、200 mg/kg；一次)治疗显示出剂量依赖性抗菌作用[2]。替卡西林(皮下注射；50、100、200 mg/kg；一次)治疗显示出良好的药代动力学评估[2]。动物模型：瑞士型雄性小鼠注射铜绿假单胞菌[2]剂量：50、100、200 mg/kg给药：皮下注射；50、100、200mg/kg；一次结果：随着剂量的增加,效应显著增加(0.001 |
| 参考文献 |
| 密度 | 1.6±0.1 g/cm3 |
|---|---|
| 沸点 | 768.3±60.0 °C at 760 mmHg |
| 分子式 | C15H16N2O6S2 |
| 分子量 | 384.427 |
| 闪点 | 418.4±32.9 °C |
| 精确质量 | 384.044983 |
| PSA | 177.55000 |
| LogP | 0.69 |
| 蒸汽压 | 0.0±2.7 mmHg at 25°C |
| 折射率 | 1.694 |
| 储存条件 | 2-8°C |
| 符号 |
GHS08 |
|---|---|
| 信号词 | Danger |
| 危害声明 | H317-H334 |
| 警示性声明 | P261-P280-P342 + P311 |
| 个人防护装备 | dust mask type N95 (US);Eyeshields;Faceshields;Gloves |
| 危害码 (欧洲) | Xn: Harmful; |
| 风险声明 (欧洲) | R42/43 |
| 安全声明 (欧洲) | 22-36/37-45 |
| 危险品运输编码 | NONH for all modes of transport |
| WGK德国 | 3 |
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Genetic characterization of oropharyngeal trichomonad isolates from wild birds indicates that genotype is associated with host species, diet and presence of pathognomonic lesions.
Avian Pathol. 43(6) , 535-46, (2014) Oropharyngeal trichomonad isolates of wild birds from Spain were studied. A total of 1688 samples (1214 of predator birds and 474 of prey species) from wildlife recovery centres and scientific bird-ri... |
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Characterization of Acinetobacter baumannii clinical isolates carrying bla(OXA-23) carbapenemase and 16S rRNA methylase armA genes in Yemen.
Microb. Drug Resist. 20(6) , 604-9, (2014) The aim of this study was to investigate the molecular support of resistance to carbapenems, aminoglycosides, and fluoroquinolones in Acinetobacter baumannii clinical isolates collected from Yemen hos... |
| (2S,5R,6R)-6-{[(2R)-2-carboxy-2-(thiophen-3-yl)acetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid |
| Temocillin Disodium |
| 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid,6-[(carboxy-3-thienylacetyl)amino]-3,3-dimethyl-7-oxo-,[2S-[2a,5a,6b(S*)]] |
| 6-[D(-)-a-Carboxy-3-thienylacetamido]penicillanic Acid |
| EINECS 252-213-5 |
| (2S,5R,6R)-6-{[(2R)-2-Carboxy-2-(3-thienyl)acetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid |
| Ticarcillin |
| (2S,5R,6R)-6-[[(2R)-2-carboxy-2-thiophen-3-yl-acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid |
| 6-[D-(-)-a-Carboxy-3-thienylacetamido]penicillanic acid |
| a-Carboxy-3-thienylmethylpenicillin |
| N-(2-Carboxy-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]hept-6-yl)-3-thiophenemalonamic Acid |
| 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[(2R)-2-carboxy-2-(3-thienyl)acetyl]amino]-3,3-dimethyl-7-oxo-, (2S,5R,6R)- |
| TRIARCILLIN |
| MFCD00864998 |
| Ticcarcillin acid |
