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4-(1-咪唑基)苯乙酮

4-(1-咪唑基)苯乙酮用途

Ro 22-3581 (4'-(Imidazol-1-yl) acetophenone) 是一种选择性的血栓烷 (TX) 合成酶抑制剂.

4-(1-咪唑基)苯乙酮名称

[ CAS 号 ]:
10041-06-2

[ 中文名 ]:
4-咪唑乙酰苯酮

[ 英文名 ]:
Ro 22-3581

[中文别名 ]:

4-咪唑-1苯乙酮

[英文别名 ]:

4’-(1-Imidazolyl)acetophenone
1-(4-(1H-Imidazol-1-yl)phenyl)ethanone
MFCD00005282
1-(4-imidazol-1-ylphenyl)ethanone
4‘-(Imidazol-1-yl)acetophenone
EINECS 233-123-5

4-(1-咪唑基)苯乙酮生物活性

[ 描述 ]:

Ro 22-3581 (4'-(Imidazol-1-yl) acetophenone) 是一种选择性的血栓烷 (TX) 合成酶抑制剂.

[ 相关类别 ]:

研究领域 >> 心血管疾病

信号通路 >> 其他 >> 其他

[ 靶点 ]

Thromboxane synthetase[1]

[参考文献]

[1]. Uderman HD, et al. Attenuation of the development of hypertension in spontaneously hypertensive rats by the thromboxane synthetase inhibitor, 4'-(imidazol-1-yl) acetophenone. Prostaglandins. 1982 Aug;24(2):237-44.

4-(1-咪唑基)苯乙酮物理化学性质

[ 密度 ]:
1.13g/cm3

[ 沸点 ]:
360.9ºC at 760 mmHg

[ 熔点 ]:
108-110 °C(lit.)

[ 分子式 ]:
C₁₁H₁₀N₂O

[ 分子量 ]:
186.21000

[ 闪点 ]:
172.1ºC

[ 精确质量 ]:
186.07900

[ PSA ]:
34.89000

[ LogP ]:
2.07490

[ 外观性状 ]:
白色至黄色粉末

[ 蒸汽压 ]:
2.15E-05mmHg at 25°C

[ 折射率 ]:
1.593

[ 储存条件 ]:
室温，干燥

4-(1-咪唑基)苯乙酮MSDS

4-(1-咪唑基)苯乙酮安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful;

[ 风险声明 (欧洲) ]:
R22;R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2933290090

4-(1-咪唑基)苯乙酮合成路线

4-(1-咪唑基)苯乙酮上下游产品

4-(1-咪唑基)苯乙酮上游产品

4-(1-咪唑基)苯乙酮下游产品

4-(1-咪唑基)苯乙酮海关

[ 海关编码 ]: 2933290090

[ 中文概述 ]:
2933290090. 其他结构含非稠合咪唑环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

4-(1-咪唑基)苯乙酮文献

Suppression of urinary albumin excretion in diabetic rats by 4'(imidazol-1-yl) acetophenone, a selective inhibitor of thromboxane synthesis.

J. Lab. Clin. Med. 116(4) , 469-78, (1990)

Thromboxane contributes to the regulation of glomerular hemodynamics in experimental models of diabetes and has been implicated as mediator in some models of glomerular injury. In the present study we...

Thromboxane and pulmonary hypertension following E. coli endotoxin infusion in sheep: effect of an imidazole derivative.

Prostaglandins 23(3) , 273-85, (1982)

We assessed the effect of a specific thromboxane synthetase inhibitor (an imidazole derivative) on pulmonary hemodynamics and the concentrations of TxB2 (TxA2), 6-keto-PGF1 alpha (PGI2), and PGF2 in p...

Attenuation of the development of hypertension in spontaneously hypertensive rats by the thromboxane synthetase inhibitor, 4'-(imidazol-1-yl) acetophenone.

Prostaglandins 24(2) , 237-44, (1982)

The compound 4'-(imidazol-1-yl) acetophenone was demonstrated to be a selective thromboxane (Tx) synthetase inhibitor in spontaneously hypertensive rats (SHR). Serum TxB2 concentrations (from clotted ...

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