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4-(3-膦酰基丙基)哌嗪-2-羧酸

4-(3-膦酰基丙基)哌嗪-2-羧酸用途

(RS)-CPP((±)-CPP)是一种强效选择性NMDA拮抗剂。(RS)-CPP抑制中枢神经元反应,具有抗惊厥活性[1]。

4-(3-膦酰基丙基)哌嗪-2-羧酸名称

[ CAS 号 ]:
100828-16-8

[ 中文名 ]:
(±)-CPP

[ 英文名 ]:
(+/-)-2-HYDROXYTRIDECANOICACID

[中文别名 ]:

[英文别名 ]:

3-2-Cpp
DL-CPP

4-(3-膦酰基丙基)哌嗪-2-羧酸生物活性

[ 描述 ]:

(RS)-CPP((±)-CPP)是一种强效选择性NMDA拮抗剂。(RS)-CPP抑制中枢神经元反应,具有抗惊厥活性[1]。

[ 相关类别 ]:

信号通路 >> 神经信号通路 >> iGluR

研究领域 >> 神经疾病

信号通路 >> 跨膜转运 >> iGluR

[参考文献]

[1]. J Davies, et al. CPP, a new potent and selective NMDA antagonist. Depression of central neuron responses, affinity for [3H]D-AP5 binding sites on brain membranes and anticonvulsant activity. Brain Res. 1986 Sep 10;382(1):169-73.

4-(3-膦酰基丙基)哌嗪-2-羧酸物理化学性质

[ 密度 ]:
1.408g/cm3

[ 沸点 ]:
546.7ºC at 760mmHg

[ 分子式 ]:
C₈H₁₇N₂O₅P

[ 分子量 ]:
252.20

[ 闪点 ]:
284.4ºC

[ 精确质量 ]:
252.08800

[ PSA ]:
119.91000

[ 蒸汽压 ]:
2.14E-13mmHg at 25°C

[ 折射率 ]:
1.53

[ 储存条件 ]:
室温，干燥，密封

4-(3-膦酰基丙基)哌嗪-2-羧酸MSDS

4-(3-膦酰基丙基)哌嗪-2-羧酸安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
36/37/38

[ 安全声明 (欧洲) ]:
22-26-36

[ 危险品运输编码 ]:
NONH for all modes of transport

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4-(3-膦酰基丙基)哌嗪-2-羧酸文献

High-content screening imaging and real-time cellular impedance monitoring for the assessment of chemical's bio-activation with regards hepatotoxicity.

Toxicol. In Vitro 29 , 1916-31, (2015)

Testing hepatotoxicity is a crucial step in the development and toxicological assessment of drugs and chemicals. Bio-activation can lead to the formation of metabolites which may present toxicity for ...

Higher vulnerability and stress sensitivity of neuronal precursor cells carrying an alpha-synuclein gene triplication.

PLoS ONE 9(11) , e112413, (2014)

Parkinson disease (PD) is a multi-factorial neurodegenerative disorder with loss of dopaminergic neurons in the substantia nigra and characteristic intracellular inclusions, called Lewy bodies. Geneti...

Regulation of AMPA receptor phosphorylation by the neuropeptide PACAP38.

Proc. Natl. Acad. Sci. U. S. A. 112 , 6712-7, (2015)

Dynamic changes in synaptic strength are thought to be critical for higher brain function such as learning and memory. Alterations in synaptic strength can result from modulation of AMPA receptor (AMP...

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