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对氨基二苯胺

对氨基二苯胺用途

用作染料及助剂的中间体

对氨基二苯胺名称

[ CAS 号 ]:
101-54-2

[ 中文名 ]:
N-苯基对苯二胺

[ 英文名 ]:
4-Aminodiphenylamine

[中文别名 ]:

[英文别名 ]:

azoic diazo no. 22
1,2-Benzenediamine, N-phenyl-
ZR DMR
p-Aminodiphenylamine
N-phenyl-1,2-phenylenediamine
Variamine Blue RT
N1-Phenylbenzene-1,4-diamine
N-Phenyl-p-Phenylenediamine
N-Phenyl-1,4-phenylenediamine
Variamine Blue RT Salt

对氨基二苯胺物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
354.7±15.0 °C at 760 mmHg

[ 熔点 ]:
69 °C

[ 分子式 ]:
C₁₂H₁₂N₂

[ 分子量 ]:
184.237

[ 闪点 ]:
197.8±24.0 °C

[ 精确质量 ]:
184.100052

[ PSA ]:
38.05000

[ LogP ]:
1.29

[ 外观性状 ]:
无气味的紫色-黑色固体或片状或暗紫色芯片

[ 蒸汽压 ]:
0.0±0.8 mmHg at 25°C

[ 折射率 ]:
1.684

[ 储存条件 ]:
库房通风低温干燥,与食品原料分开储运

[ 水溶解性 ]:
水溶性：微溶；可溶于：醇,乙醚,丙酮

对氨基二苯胺MSDS

对氨基二苯胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: ST3150000

CHEMICAL NAME :: p-Phenylenediamine, N-phenyl-

CAS REGISTRY NUMBER :: 101-54-2

LAST UPDATED :: 199710

DATA ITEMS CITED :: 15

MOLECULAR FORMULA :: C12-H12-N2

MOLECULAR WEIGHT :: 184.26

WISWESSER LINE NOTATION :: ZR DMR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 464 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 244 mg/kg

TOXIC EFFECTS :: Blood - hemorrhage Nutritional and Gross Metabolic - body temperature decrease

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - cyanosis Blood - methemoglobinemia-carboxyhemoglobin

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - food intake (animal)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 13500 mg/kg/90D-C

TOXIC EFFECTS :: Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Blood - changes in erythrocyte (RBC) count Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 150 ug/plate

REFERENCE :: ESKHA5 Eisei Shikenjo Hokoku. Bulletin of the Institute of Hygienic Sciences. (Kokuritsu Eisei Shikenjo Kagaku, 18-1 Bushitsu Johobu, Setagaya-ku, Tokyo 158, Japan) V.1- 1886- Volume(issue)/page/year: (94),28,1976 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83649 No. of Facilities: 211 (estimated) No. of Industries: 4 No. of Occupations: 20 No. of Employees: 7379 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83649 No. of Facilities: 63 (estimated) No. of Industries: 4 No. of Occupations: 11 No. of Employees: 4356 (estimated) No. of Female Employees: 530 (estimated)

对氨基二苯胺安全信息

[ 符号 ]:

GHS07, GHS09

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H317-H319-H410

[ 警示性声明 ]:
P273-P280-P305 + P351 + P338-P501

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful;

[ 风险声明 (欧洲) ]:
R20/22;R36/37/38;R42/43

[ 安全声明 (欧洲) ]:
S26-S36-S45-S36/37/39

[ 危险品运输编码 ]:
UN3077

[ WGK德国 ]:
3

[ RTECS号 ]:
ST3150000

[ 包装等级 ]:
III

[ 危险类别 ]:
9

[ 海关编码 ]:
29215990

对氨基二苯胺合成路线

对氨基二苯胺上下游产品

对氨基二苯胺上游产品

对氨基二苯胺下游产品

对氨基二苯胺制备

1.国内外采用的生产路线有4-硝基二苯胶还原法和4-亚硝基二苯胺还原法。前者根据所用原料又分为苯胺和甲酰胺法。而4-亚硝基二苯胺法，因以二苯胶为原料，又称二苯胺法。另外还有皂黄还原的方法。(1).苯胺法对硝基氯苯与苯胺（摩尔比1：1.78）在铜催化剂（例如氧化铜和缚酸剂碳酸钾）的存在下，于170-215℃常压缩合14h，得4-硝基二苯胺，以对硝基氯苯计，收率90.6%。原料消耗定额：对硝基氯苯1100kg/t、苯胺820kg/t、甲酸500kg/t、碳酸钾650kg/t、硫化碱1950kg/t。(2).甲酰苯胺法甲酸与苯胺缩合得甲酰苯胺，再与对硝基氯苯（甲酰苯胺的用量比理论量过量0%-100%），在缚酸剂碳酸钾的存在下，于120-195℃反应，即得4-硝基二苯胺。以上二法所得4-硝基二苯胺可采用硫化碱或加氢还原，亦可在20-50℃电化学还原，收率96%。(3).4-亚硝基二苯胺法二苯胺在酸存在下，于溶剂中用亚硝酸盐进行亚硝化，得N-亚硝基二苯胺，再用无水氯化氢进行转位、重排即得4-亚硝基二苯胺，收率为98%-99%。亚硝化、转位、重排的温度为17-30℃。4-亚硝基二苯胺可于50-100℃用硫化碱在常压下还原，亦可采用催化加氢还原。近年研究发展的以镍为催化剂的加氢还原，收率可达97%-98%。4-亚硝基二苯胺也可采用电化学还原得到RT培司，收率96%。(4).皂黄还原法在反应釜中加入55L水、23kg50%硫化钠，6.6kg硫，在搅拌下加热至沸腾，使物料全部溶解，然后再加入280L水，42.4kg100%皂黄，密闭反应釜，升温至135℃，热压5h。冷到室温后，过滤，清水淋洗至滤液不呈黄色，得100%4-氨基二苯胺19.9kg。收率90%。

对氨基二苯胺海关

[ 海关编码 ]: 2921590090

[ 中文概述 ]:
2921590090. 其他芳香多胺及衍生物及它们的盐. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2921590090. other aromatic polyamines and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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