2,2-二溴-3-次氮基丙酰胺

2,2-二溴-3-次氮基丙酰胺用途

【用途一】
用作医药中间体、杀菌灭藻剂、工业污水处理剂等
【用途二】
该品是一种广谱高效的杀生物剂。它的分子能迅速穿透微生物的细胞膜，并作用于一定的蛋白基团，使细胞正常的氧化-还原终止，从而引起细胞死亡。此外，它的分子还能选择性地溴化或氧化微生物体内的特殊的酶代谢物，最终导致微生物死亡。主要用作杀菌灭藻剂，用来防止细菌和藻类在造纸工业用水、工业用冷却水、空调用水、金属加工用润滑油、水乳化液、纸浆、木材、胶合板和涂料，以及纤维中生长。采用15ppm20%的DBNPA，就能达到良好的效果。不仅能控制住微生物，而且还能剥离掉原塞满填料的粘泥团块，恢复冷却塔的蒸发效率。该品对动物的毒性为中等，雌豚鼠LD50为118mg/kg。

2,2-二溴-3-次氮基丙酰胺名称

[ CAS 号 ]:
10222-01-2

[ 中文名 ]:
2,2-二溴-3-氮川丙酰胺

[ 英文名 ]:
2,2-Dibromo-2-cyanoacetamide

[中文别名 ]:

[英文别名 ]:

2,2-Dibromo-3-nitrilopropionamide
Cyanodibromoacetamide
EINECS 233-539-7
MFCD00129791
Dbnpa
ZVXEECN
Acetamide, 2,2-dibromo-2-cyano-
Dibromocyano acetic acid amide
dibromocyanoacetamide
2,2-Dibromo-2-cyanoacetamide

2,2-二溴-3-次氮基丙酰胺物理化学性质

[ 密度 ]:
2.5±0.1 g/cm3

[ 沸点 ]:
221.5±40.0 °C at 760 mmHg

[ 熔点 ]:
122-125 °C(lit.)

[ 分子式 ]:
C₃H₂Br₂N₂O

[ 分子量 ]:
241.869

[ 闪点 ]:
87.8±27.3 °C

[ 精确质量 ]:
239.853378

[ PSA ]:
66.88000

[ LogP ]:
1.51

[ 外观性状 ]:
无色至黄色液体带有一种发霉的辛辣气味

[ 蒸汽压 ]:
0.1±0.4 mmHg at 25°C

[ 折射率 ]:
1.625

[ 储存条件 ]:
Refrigerator

[ 稳定性 ]:
Stable, but may be moisture sensitive. Incompatible with strong oxidizing agents.

[ 水溶解性 ]:
水溶性：微溶；水溶解度：15 g/l ；可溶于：甲醇,丙酮,乙醇；微溶：苯,甲苯

2,2-二溴-3-次氮基丙酰胺MSDS

详细MSDS(安全技术说明书)

2,2-二溴-3-次氮基丙酰胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AB5956000

CHEMICAL NAME :: Acetamide, 2-cyano-2,2-dibromo-

CAS REGISTRY NUMBER :: 10222-01-2

BEILSTEIN REFERENCE NO. :: 1761192

LAST UPDATED :: 199710

DATA ITEMS CITED :: 10

MOLECULAR FORMULA :: C3-H2-Br2-N2-O

MOLECULAR WEIGHT :: 241.89

WISWESSER LINE NOTATION :: ZVXEECN

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: PHMCAA Pharmacologist. (American Soc. for Pharmacology and Experimental Therapeutics, 9650 Rockville Pike, Bethesda, MD 20014) V.1- 1959- Volume(issue)/page/year: 15,226,1973

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: PHMCAA Pharmacologist. (American Soc. for Pharmacology and Experimental Therapeutics, 9650 Rockville Pike, Bethesda, MD 20014) V.1- 1959- Volume(issue)/page/year: 15,226,1973 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 10 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#07898

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 118 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PHMCAA Pharmacologist. (American Soc. for Pharmacology and Experimental Therapeutics, 9650 Rockville Pike, Bethesda, MD 20014) V.1- 1959- Volume(issue)/page/year: 15,226,1973 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X1009 No. of Facilities: 369 (estimated) No. of Industries: 25 No. of Occupations: 10 No. of Employees: 9829 (estimated) No. of Female Employees: 108 (estimated)

2,2-二溴-3-次氮基丙酰胺安全信息

[ 符号 ]:

GHS05, GHS07, GHS09

[ 信号词 ]:
Danger

[ 危害声明 ]:
H314-H317-H400

[ 警示性声明 ]:
P273-P280-P305 + P351 + P338-P310

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
Xn:Harmful

[ 风险声明 (欧洲) ]:
R20/21/22

[ 安全声明 (欧洲) ]:
S26-S36/37/39-S45-S36/37

[ 危险品运输编码 ]:
UN 1759 8/PG 3

[ WGK德国 ]:
3

[ RTECS号 ]:
AB5956000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

[ 海关编码 ]:
2926909090

2,2-二溴-3-次氮基丙酰胺合成路线

详细合成路线

2,2-二溴-3-次氮基丙酰胺上下游产品

2,2-二溴-3-次氮基丙酰胺上游产品

2,2-二溴-3-次氮基丙酰胺下游产品

2,2-二溴-3-次氮基丙酰胺制备

1.可以氯乙酸、氰乙酸、二烷基氨基丙烯醛、氨基缩醛二醇和氰乙酸甲酯为起始原料，先制取氰乙酰胺，再进行溴化反应而得该品。

2.以氯乙酸为起始原料的合成方法：将氯乙酸用碳酸钠或氢氧化钠进行中和，制取氯乙酸钠，然后在丁醇溶液中与氰化钠反应，生成氰乙酸钠。用浓盐酸酸化，将所得的氰乙酸与甲醇或丁醇进行酯化反应，生成氰乙酸甲酯，经胺解成氰乙酰胺，最后溴化即得DBNPA。溴化可采用溴素、溴化氢和溴酸钠或氯酸钠等
原料，反应介质可选用聚乙二醇、水等，反应温度一般控制在40℃以下，以减少DBNPA的分解。

2,2-二溴-3-次氮基丙酰胺海关

[ 海关编码 ]: 2926909090

[ 中文概述 ]:
2926909090 其他腈基化合物. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
HS:2926909090 other nitrile-function compounds VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

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