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GDP-Mannose二钠盐

GDP-Mannose二钠盐用途

GDP-α-D-甘露糖二钠是甘露糖转移酶的供体底物和GDP-β-L-岩藻糖的前体。GDP-α-D-甘露糖二钠对GTP(Ki 14.7μM)具有竞争性抑制作用,对甘露糖-1-P(Ki 115μM)具有非竞争性抑制作用[1]。

GDP-Mannose二钠盐名称

[ CAS 号 ]:
103301-73-1

[ 中文名 ]:
鸟苷5'-(二磷酸三氢)P'-D-吡喃甘露糖酯二钠盐

[ 英文名 ]:
GDP-ALPHA-D-MANNOSE, DISODIUM SALT

[英文别名 ]:

GDP-α-D-MANNOSE, DISODIUM SALT

GDP-Mannose二钠盐生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 代谢疾病

[ 靶点 ]

Human Endogenous Metabolite

[参考文献]

[1]. Elling L, et al. Expression, purification and characterization of recombinant phosphomannomutase and GDP-alpha-D-mannose pyrophosphorylase from Salmonella enterica, group B, for the synthesis of GDP-alpha-D-mannose from D-mannose. Glycobiology. 1996 Sep;6(6):591-7.

GDP-Mannose二钠盐物理化学性质

[ 分子式 ]:
C₁₆H₂₃N₅Na₂O₁₆P₂

[ 分子量 ]:
649.30

[ 精确质量 ]:
649.04100

[ PSA ]:
357.00000

[ 储存条件 ]:
-20°C

GDP-Mannose二钠盐安全信息

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
R22

[ 安全声明 (欧洲) ]:
S26

[ 危险品运输编码 ]:
NONH for all modes of transport

GDP-Mannose二钠盐文献

Low glucose depletes glycan precursors, reduces site occupancy and galactosylation of a monoclonal antibody in CHO cell culture.

Biotechnol. J. 10 , 1051-66, (2015)

Controlled feeding of glucose has been employed previously to enhance the productivity of recombinant glycoproteins but there is a concern that low concentrations of glucose could limit the synthesis ...

Structural and Enzymatic Characterization of a Nucleoside Diphosphate Sugar Hydrolase from Bdellovibrio bacteriovorus.

PLoS ONE 10 , e0141716, (2015)

Given the broad range of substrates hydrolyzed by Nudix (nucleoside diphosphate linked to X) enzymes, identification of sequence and structural elements that correctly predict a Nudix substrate or cha...

Aging without Apolipoprotein D: Molecular and cellular modifications in the hippocampus and cortex.

Exp. Gerontol. 67 , 19-47, (2015)

A detailed knowledge of the mechanisms underlying brain aging is fundamental to understand its functional decline and the baseline upon which brain pathologies superimpose. Endogenous protective mecha...

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