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甘氨酸酐

甘氨酸酐用途

【用途一】
用作生化试剂。被碱、酸或热水水解可得甘氨酰甘氨酸。

甘氨酸酐名称

[ CAS 号 ]:
106-57-0

[ 中文名 ]:
甘氨酸酐

[ 英文名 ]:
Glycine Anhydride

[中文别名 ]:

[英文别名 ]:

piperazine-2,5-dione
EINECS 203-411-5
Glycocoll Anhydride
Cyclodiglycine
2,5-Diketopiperazine
2,5-Pyrazinediol, 3,6-dihydro-
3,6-Dihydro-2,5-pyrazinediol
5-24-05-00294 (Beilstein Handbook Reference)
2,5-Piperazinedione
Glycine Anhydride

甘氨酸酐物理化学性质

[ 密度 ]:
1.2±0.1g/cm3

[ 沸点 ]:
573.7±43.0°C at 760 mmHg

[ 熔点 ]:
300°C

[ 分子式 ]:
C₄H₆N₂O₂

[ 分子量 ]:
114.103

[ 闪点 ]:
301.9±28.3°C

[ 精确质量 ]:
114.042931

[ PSA ]:
58.20000

[ LogP ]:
-2.93

[ 外观性状 ]:
白色至略黄色结晶粉末

[ 蒸汽压 ]:
0.0±2.0 mmHg at 25°C

[ 折射率 ]:
1.649

[ 储存条件 ]:
2~8℃

甘氨酸酐MSDS

甘氨酸酐毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TL6325250

CHEMICAL NAME :: 2,5-Piperazinedione

CAS REGISTRY NUMBER :: 106-57-0

BEILSTEIN REFERENCE NO. :: 0112112

LAST UPDATED :: 199701

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C4-H6-N2-O2

MOLECULAR WEIGHT :: 114.12

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CBCCT* "Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. (National Academy of Science Library, 2101 Constitution Ave., NW, Washington, DC 20418) Volume(issue)/page/year: 6,227,1954

甘氨酸酐安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xn

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
TL6325250

[ 海关编码 ]:
2933599090

甘氨酸酐合成路线

甘氨酸酐上下游产品

甘氨酸酐上游产品

甘氨酸酐下游产品

甘氨酸酐制备

由甘氨酸缩合而得。将甘氨酸与乙二胺按1：5混合后搅拌加热，174-176℃反应50min，然后置于冰室中过认，过滤出结晶，用甲醇洗涤，干燥得甘氨酰酐。也可以由甘氨酸在脱水的甘油中缩合而制备。

甘氨酸酐海关

[ 海关编码 ]: 2933599090

[ 中文概述 ]:
2933599090. 其他结构上有嘧啶环的化合物(包括其他结构上有哌嗪环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

甘氨酸酐文献

Design and synthesis of novel soluble 2,5-diketopiperazine derivatives as potential anticancer agents.

Eur. J. Med. Chem. 83 , 236-44, (2014)

Non-protected 2,5-diketopiperazine derivatives have poor solubility thus with negative impact on their bioavailability. In the present study, twenty-one novel soluble mono-protected, and three non-pro...

Rational design and combinatorial evaluation of enzyme inhibitor scaffolds: identification of novel inhibitors of matrix metalloproteinases.

J. Med. Chem. 41(13) , 2194-200, (1998)

The discovery of a novel series of heterocyclic matrix metalloproteinase (MMPs) inhibitors is described. Published crystal structures of peptidyl hydroxamates bound to MMPs were the basis for the rati...

Diagnostic NH and OH vibrations for oxazolone and diketopiperazine structures: b2 from protonated triglycine.

J. Am. Soc. Mass Spectrom. 22 , 1197-1203, (2011)

We present infrared multiple photon dissociation (IRMPD) spectra in the hydrogen stretching region of the simplest b fragment, b(2) from protonated triglycine, contrasted to that of protonated cyclo(G...

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