<生产厂家 价格>

1,3-丁二醇

1,3-丁二醇用途

1,3-Butanediol,一种乙醇二聚体,为人体营养提供热量来源。1,3-Butanediol 在体内转化为 β-羟基丁酸酯,并具有脑保护和降血糖作用。

1,3-丁二醇名称

[ CAS 号 ]:
107-88-0

[ 中文名 ]:
1,3-丁二醇

[ 英文名 ]:
1,3-Butanediol

[中文别名 ]:

[英文别名 ]:

1,3-丁二醇生物活性

[ 描述 ]:

1,3-Butanediol,一种乙醇二聚体,为人体营养提供热量来源。1,3-Butanediol 在体内转化为 β-羟基丁酸酯,并具有脑保护和降血糖作用。

[ 相关类别 ]:

研究领域 >> 心血管疾病
研究领域 >> 神经疾病

[参考文献]

[1]. C Marie, et al. Protective action of 1,3-butanediol in cerebral ischemia. A neurologic, histologic, and metabolic study. J Cereb Blood Flow Metab. 1987 Dec;7(6):794-800.

[2]. R B Tobin,et al. Nutritional and metabolic studies in humans with 1,3-butanediol. Fed Proc. 1975 Nov;34(12):2171-6.

1,3-丁二醇物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
207.0±0.0 °C at 760 mmHg

[ 熔点 ]:
-54ºC

[ 分子式 ]:
C4H10O2

[ 分子量 ]:
90.121

[ 闪点 ]:
121.1±0.0 °C

[ 精确质量 ]:
90.068077

[ PSA ]:
40.46000

[ LogP ]:
-0.69

[ 外观性状 ]:
黏的液体,无气味

[ 蒸汽密度 ]:
3.1 (20 °C, vs air)

[ 蒸汽压 ]:
0.1±0.8 mmHg at 25°C

[ 折射率 ]:
1.438

[ 储存条件 ]:
库房通风低温干燥,防火,与氧化剂分开存放

[ 稳定性 ]:
Stable. Flammable. Hygroscopic - protect from air and moisture. Incompatible with strong oxidizing agents.

[ 水溶解性 ]:
SOLUBLE

1,3-丁二醇MSDS

1,3-丁二醇毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
EK0440000
CHEMICAL NAME :
1,3-Butanediol
CAS REGISTRY NUMBER :
107-88-0
BEILSTEIN REFERENCE NO. :
1731276
LAST UPDATED :
199712
DATA ITEMS CITED :
17
MOLECULAR FORMULA :
C4-H10-O2
MOLECULAR WEIGHT :
90.14
WISWESSER LINE NOTATION :
QY1&2Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,207,1986
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE :
AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918- Volume(issue)/page/year: 29,1363,1946
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,207,1986 ** ACUTE TOXICITY DATA **
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
18610 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 23,259,1941
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
20 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NPIRI* Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. (National Assoc. of Printing Ink Research Institute, Francis McDonald Sinclair Memorial Laboratory, Lehigh Univ., Bethlehem, PA 18015) Volume(issue)/page/year: 1,14,1974
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
12980 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 45,669,1956
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
10276 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 49,385,1979
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
>20 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NPIRI* Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. (National Assoc. of Printing Ink Research Institute, Francis McDonald Sinclair Memorial Laboratory, Lehigh Univ., Bethlehem, PA 18015) Volume(issue)/page/year: 1,14,1974
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
11 gm/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Gastrointestinal - other changes Kidney, Ureter, Bladder - other changes
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 23,259,1941 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
42360 mg/kg
SEX/DURATION :
female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
REFERENCE :
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 5(4),189,1986 *** REVIEWS *** TOXICOLOGY REVIEW JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 4(5),223,1985 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83068 No. of Facilities: 1532 (estimated) No. of Industries: 13 No. of Occupations: 22 No. of Employees: 36963 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83068 No. of Facilities: 1070 (estimated) No. of Industries: 13 No. of Occupations: 17 No. of Employees: 19336 (estimated) No. of Female Employees: 5266 (estimated)

1,3-丁二醇安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;half-mask respirator (US);multi-purpose combination respirator cartridge (US)

[ 危害码 (欧洲) ]:
F

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
1

[ RTECS号 ]:
EK0440000

[ 海关编码 ]:
2905399090

1,3-丁二醇上下游产品

1,3-丁二醇上游产品

1,3-丁二醇下游产品

1,3-丁二醇制备

1. 由乙醛在碱水中进行醇醛缩合成3-美基丁醛,再加氢还原而得。


2. 由丙烯与甲醛在硫酸存在下缩合而成。

3.采用乙醛缩合法。在氢氧化钠存在下,将乙醛缩合得丁醇醛,以镍作催化剂,经加氢得粗品,再经冷却、分离镍、减压蒸馏而得。

1,3-丁二醇海关

[ 海关编码 ]: 2905399090

[ 中文概述 ]:
2905399090 其他二元醇。监管条件:AB(入境货物通关单,出境货物通关单)。增值税率:17.0%。退税率:9.0%。最惠国关税:5.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 包装

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验 M.进口商品检验 N.出口商品检验

[ Summary ]:
2905399090 other diols。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:5.5%。general tariff:30.0%

1,3-丁二醇文献

Non-animal photosafety screening for complex cosmetic ingredients with photochemical and photobiochemical assessment tools.

Regul Toxicol Pharmacol 72 , 578-85, (2015)

Previously, a non-animal screening approach was proposed for evaluating photosafety of cosmetic ingredients by means of in vitro photochemical and photobiochemical assays; however, complex cosmetic in...

Synergistic topical application of salt-processed Phellodendron amurense and Sanguisorba officinalis Linne alleviates atopic dermatitis symptoms by reducing levels of immunoglobulin E and pro-inflammatory cytokines in NC/Nga mice.

Mol. Med. Report. 12 , 7657-64, (2015)

Atopic dermatitis is a chronic inflammatory skin disease, and salt-processed Phellodendron amurense (CPE) and Sanguisorba officinalis Linne (SOE) are widely used as anti-inflammatory agents in Asia. T...

In vitro and in vivo evaluation under finite conditions of a transdermal oil-in-water type emulsified formulation of propiverine hydrochloride.

Biol. Pharm. Bull. 37(10) , 1661-7, (2014)

A transdermal oil-in-water type emulsified formulation containing propiverine hydrochloride, used for treatment of an overactive bladder (OAB), was evaluated for in vitro skin permeation under finite ...


更多文献

相关化工产品/化学物质:

推荐生产厂家/供应商:

公司名:上海化源世纪贸易有限公司

区域:上海市普陀区

价格:

联系人:徐经理

产品详情:1,3-丁二醇


公司名:南通润丰石油化工有限公司

区域:南通市崇川区

价格:
¥需询单/1kg ¥需询单/1ton

联系人:曹经理

产品详情:1,3-丁二醇


公司名:上海吉至生化科技有限公司

区域:上海市奉贤区

价格:
¥78.0/500ml

联系人:刘佳

产品详情:1,3-丁二醇


公司名:上海创赛科技有限公司

区域:上海市嘉定区

价格:
¥37.0/100ml ¥95.0/500ml ¥352.0/2500ml ¥1356.0/10l

联系人:夏言

产品详情:[Perfemiker]1,3-丁二醇,99%


公司名:上海阿拉丁生化科技股份有限公司

区域:上海市浦东新区

价格:
¥51.9/100g ¥339.9/3kg ¥39.9/25g ¥128.9/500g

联系人:阿拉丁

产品详情:1,3-丁二醇


查看所有供应商请点击:

1,3-丁二醇供应商


相关化合物

【1,3-丁二醇】化源网提供1,3-丁二醇CAS号107-88-0,1,3-丁二醇MSDS及其说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。CAS号查询1,3-丁二醇上化源网,专业又轻松。>>电脑版:1,3-丁二醇

标题:1,3-丁二醇_MSDS_用途_密度_CAS号【107-88-0】_化源网 地址:https://www.chemsrc.com/amp/cas/107-88-0_593062.html