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间苯二酚

间苯二酚用途

Resorcinol是一种防腐剂及消毒剂,是用于生产其他药品的化学中间体。用于治疗痤疮,脂溢性皮炎,湿疹,银屑病和其它皮肤疾病。

间苯二酚名称

[ CAS 号 ]:
108-46-3

[ 中文名 ]:
间苯二酚

[ 英文名 ]:
Resorcine

[中文别名 ]:

[英文别名 ]:

1,3-diethynylenebenzene
1,3-benzenediol
Benzene,1,3-diethynyl
1,3-hydroquinone
meta-dihydroxy benzene
Resorcine
m-diethynylbenzene
meta-diethynylbenzene
2,3-Pyridinedicarboxylic acid
1,3-Benzenediol,Resorcinolum

间苯二酚生物活性

[ 描述 ]:

Resorcinol是一种防腐剂及消毒剂,是用于生产其他药品的化学中间体。用于治疗痤疮,脂溢性皮炎,湿疹,银屑病和其它皮肤疾病。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 炎症/免疫

[相关活性小分子]

间苯二酚物理化学性质

[ 密度 ]:
1.27

[ 沸点 ]:
281 ºC

[ 熔点 ]:
109-111°C

[ 分子式 ]:
C₆H₆O₂

[ 分子量 ]:
110.111

[ 闪点 ]:
127 ºC

[ 精确质量 ]:
110.036781

[ PSA ]:
40.46000

[ LogP ]:
0.76

[ 外观性状 ]:
晶体或粉末

[ 蒸汽密度 ]:
3.8 (vs air)

[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C

[ 折射率 ]:
1.612

[ 储存条件 ]:
0-6°C

[ 水溶解性 ]:
140 g/100 mL

间苯二酚MSDS

详细MSDS(安全技术说明书)

间苯二酚毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VG9625000

CHEMICAL NAME :: Resorcinol

CAS REGISTRY NUMBER :: 108-46-3

BEILSTEIN REFERENCE NO. :: 0906905

LAST UPDATED :: 199712

DATA ITEMS CITED :: 57

MOLECULAR FORMULA :: C6-H6-O2

MOLECULAR WEIGHT :: 110.12

WISWESSER LINE NOTATION :: QR CQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human

DOSE/DURATION :: 29 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 301 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Gastrointestinal - changes in structure or function of salivary glands Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 160 mg/m3/1H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Behavioral - excitement Behavioral - tetany Behavioral - coma

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 215 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 213 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 700 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 110 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Blood - methemoglobinemia-carboxyhemoglobin

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 3360 mg/kg

TOXIC EFFECTS :: Skin and Appendages - primary irritation (after topical exposure) Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Behavioral - excitement Behavioral - tetany Behavioral - coma

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Amphibian - frog

DOSE/DURATION :: 270 mg/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - convulsions or effect on seizure threshold Cardiac - other changes

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5400 mg/kg/17D-I

TOXIC EFFECTS :: Endocrine - changes in thymus weight

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 8450 mg/kg/13W-I

TOXIC EFFECTS :: Liver - changes in liver weight Endocrine - changes in adrenal weight

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 504 mg/kg/28D-C

TOXIC EFFECTS :: Endocrine - changes in adrenal weight

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3600 mg/kg/17D-I

TOXIC EFFECTS :: Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 27300 mg/kg/13W-I

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4800 mg/kg/12W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Rodent - hamster Ovary

REFERENCE :: CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year: 14,251,1981 *** REVIEWS *** ACGIH TLV-Not classifiable as a human carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-STEL 90 mg/m3 (20 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 45 mg/m3 (10 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 15,155,1977 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 15,155,1977 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 TOXICOLOGY REVIEW MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 47,75,1978 TOXICOLOGY REVIEW JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 5(3),167,1986 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 10 ppm (45 mg/m3);STEL 20 ppm (90 mg/m3) JAN 1993 OEL-BELGIUM:TWA 10 ppm (45 mg/m3);STEL 20 ppm (90 mg/m3) JAN 1993 OEL-DENMARK:TWA 10 ppm (45 mg/m3) JAN 1993 OEL-FINLAND:TWA 10 ppm (45 mg/m3);STEL 20 ppm (90 mg/m3) JAN 1993 OEL-FRANCE:TWA 10 ppm (45 mg/m3) JAN 1993 OEL-HUNGARY:TWA 45 mg/m3;STEL 90 mg/m3;Skin JAN 1993 OEL-THE NETHERLANDS:TWA 10 ppm (45 mg/m3) JAN 1993 OEL-SWITZERLAND:TWA 10 ppm (45 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 10 ppm (45 mg/m3);STEL 20 ppm (90 mg/m3) JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO RESORCINAL-air:10H TWA 10 ppm;STEL 20 ppm REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 67220 No. of Facilities: 4488 (estimated) No. of Industries: 45 No. of Occupations: 42 No. of Employees: 40431 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 67220 No. of Facilities: 6842 (estimated) No. of Industries: 30 No. of Occupations: 43 No. of Employees: 100792 (estimated) No. of Female Employees: 56465 (estimated)

间苯二酚安全信息

[ 符号 ]:

GHS07, GHS08, GHS09

[ 信号词 ]:
Danger

[ 危害声明 ]:
H302-H315-H317-H319-H370-H410

[ 警示性声明 ]:
P260-P273-P280-P308 + P311-P333 + P313-P337 + P313

[ 靶器官 ]:
Blood, Central nervous system, Respiratory system

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful

[ 风险声明 (欧洲) ]:
R22;R36/38;R50

[ 安全声明 (欧洲) ]:
S26;S61

[ 危险品运输编码 ]:
UN 2876 6.1/PG 3

[ WGK德国 ]:
2

[ RTECS号 ]:
VG9625000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1

[ 海关编码 ]:
2907210000

间苯二酚合成路线

详细合成路线

间苯二酚上下游产品

间苯二酚上游产品

间苯二酚下游产品

间苯二酚制备

1.间苯二酚的制备方法较多，如苯磺化碱熔法、间苯二酚与苯酚联产法、间苯二胺法、间二异丙苯法、间氨基苯酚水解法等。苯磺化碱熔法以苯为原料，经磺化得间苯二磺酸，再经中和碱熔、酸化而得。
将苯、65％发烟硫酸和硫酸钠分别加入反应器中，控制反应温度在75℃，得磺化物。然后向此磺化物中加入无水硫酸钠，搅拌加热至175℃使其溶解，在此温度下加入三氧化硫，再反应1.5h，得二磺化物(苯二磺酸含量75％)。将二磺化物用稀碱液中和，并除去过量的硫酸盐后，所得苯二磺酸钠盐在290℃下逐渐加到熔化的氢氧化钠中，在15min内升温至325℃，而后将碱熔物溶于水，用硫酸酸化，再用乙醚萃取，蒸出溶剂，即得间苯二酚成品。

2.间苯二磺酸钾经碱熔、酸化后即可得到此产品。

操作步骤为：将苯、60%发烟硫酸和硫酸钠加入反应锅中，控制反应温度75℃，所得磺化物含苯磺酸75%、二苯砜1%、硫酸20%、硫酸钠4%。然后加入无水硫酸钠，搅拌加热至175℃，加入三氧化硫再反应1.5h，所得产物组成为苯二磺酸75%、二苯砜二磺4%、硫酸17%、硫酸钠4%。经稀碱中和并除去过量的硫酸盐后，得到苯二磺酸钠盐，于290℃加入熔融的氢氧化钠中，15min内升温至325℃。将碱溶物溶于水，用硫酸酸化，再用乙醚或丁醇萃取，萃取液蒸馏回收溶剂后即得粗品，将粗品减压蒸馏，收集178℃馏分即为间苯二酚。

3.间二异丙苯氧化法（HOP法）：间二异丙苯氧化法是一种类似于异丙苯氧化制苯酚和丙酮的方法。苯与丙烯在催化剂作用下进行烷基化反应生成间二异丙苯，间二异丙苯在80～90℃、弱碱性条件下通入氧气和空气进行氧化反应生成二氢过氧化间二异丙苯和副产物间二异丙苯羟基过氧化物，经结晶、过滤分离出二氢过氧化间二异丙苯，再在80℃条件下用硫酸或磷酸解离得间苯二酚和丙酮。随着环保要求的日益严格，该法将成为工业上合成间苯二酚的发展方向。

间苯二酚海关

[ 海关编码 ]: 2907210000

[ 中文概述 ]:
2907210000 间苯二酚及其盐。监管条件:无。增值税率:17.0%。退税率:9.0%。最低关税:5.5%。普通关税:30.0%

[ Summary ]:
2907210000 resorcinol。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。Lowest tariff:5.5%。General tariff:30.0%

间苯二酚文献

Nanoporous Cathodes for High-Energy Li-S Batteries from Gyroid Block Copolymer Templates.

ACS Nano 9 , 6147-57, (2015)

This study reports on a facile approach to the fabrication of nanoporous carbon cathodes for lithium sulfur batteries using gyroid carbon replicas based on use of polystyrene-poly-4-vinylpyridine (PS-...

Molecular characterization of the boron adducts of the proteasome inhibitor bortezomib with epigallocatechin-3-gallate and related polyphenols.

Org. Biomol. Chem. 13(13) , 3887-99, (2015)

The green tea polyphenol epigallocatechin-3-gallate (EGCG) was reported to effectively antagonize the ability of Bortezomib (BZM) to induce apoptosis in cancer cells. This interaction was attributed t...

Synthesis, luminescence, and electrochemical studies of a new series of octanuclear ruthenium(II) complexes of tolylterpyridine appended calixresorcarenes.

Dalton Trans. 44 , 14813-22, (2015)

A new series of octanuclear Ru(ii) complexes of tolylterpyridine appended calixresorcarenes [{Ru(ttpy)}8()](PF6)16 (), [{Ru(ttpy)}8()](PF6)16 (), and [{Ru(ttpy)}8()](PF6)16 () [ = 2,8,14,20-tetraethyl...

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