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异胞嘧啶

异胞嘧啶用途

Isocytosine是一种非天然核酸碱基,是胞嘧啶的异构体。与异鸟嘌呤联合用于研究DNA正常碱基对的非自然核酸类似物,也可用作hachimoji RNA 的核酸碱基。

异胞嘧啶名称

[ CAS 号 ]:
108-53-2

[ 中文名 ]:
异胞嘧啶

[ 英文名 ]:
Isocytosine

[中文别名 ]:

[英文别名 ]:

4(1H)-Pyrimidinone, 2-amino- (9CI)
2-amino-4-oxo-3,4-dihydropyrimidine
4(3H)-pyrimidinone, 2-amino-
2-amino-3H-pyrimidin-4-one
Isocytosine
2-Amino-4-pyrimidone
2-Aminopyrimidin-4-ol
2-amino-4-hydroxypyrimine
2-Amino-4-hydroxypyrimidine
4-Hydroxy-2-aminopyrimidine

异胞嘧啶生物活性

[ 描述 ]:

Isocytosine是一种非天然核酸碱基,是胞嘧啶的异构体。与异鸟嘌呤联合用于研究DNA正常碱基对的非自然核酸类似物,也可用作hachimoji RNA 的核酸碱基。

[ 相关类别 ]:

信号通路 >> 细胞周期/DNA损伤 >> 核苷抗代谢药/类似物

研究领域 >> 其他

[参考文献]

[1]. "Isocytosine". Molecule of the Week. American Chemical Society. Retrieved November 1, 2012.

[2]. Hoshika S, et al. Hachimoji DNA and RNA: A genetic system with eight building blocks. Science. 2019 Feb 22;363(6429):884-887.

异胞嘧啶物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 沸点 ]:
393.6±34.0 °C at 760 mmHg

[ 熔点 ]:
275°C

[ 分子式 ]:
C₄H₅N₃O

[ 分子量 ]:
111.102

[ 闪点 ]:
191.9±25.7 °C

[ 精确质量 ]:
111.043259

[ PSA ]:
72.03000

[ LogP ]:
-1.01

[ 外观性状 ]:
白色至灰白色固体

[ 蒸汽压 ]:
0.0±0.9 mmHg at 25°C

[ 折射率 ]:
1.668

[ 储存条件 ]:
Room temperature.

异胞嘧啶MSDS

异胞嘧啶安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H319

[ 警示性声明 ]:
P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful;

[ 风险声明 (欧洲) ]:
R22;R36

[ 安全声明 (欧洲) ]:
S26

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2933599090

异胞嘧啶合成路线

异胞嘧啶上下游产品

异胞嘧啶上游产品

异胞嘧啶下游产品

异胞嘧啶海关

[ 海关编码 ]: 2933599090

[ 中文概述 ]:
2933599090. 其他结构上有嘧啶环的化合物(包括其他结构上有哌嗪环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

异胞嘧啶文献

Lead optimization of isocytosine-derived xanthine oxidase inhibitors.

Bioorg. Med. Chem. Lett. 23(3) , 834-8, (2013)

We report our attempts at improving the oral efficacy of low-nanomolar inhibitors of xanthine oxidase from isocytosine series through chemical modifications. Our lead compound had earlier shown good i...

Isocytosine-based inhibitors of xanthine oxidase: Design, synthesis, SAR, PK and in vivo efficacy in rat model of hyperuricemia

Bioorg. Med. Chem. Lett. 22(24) , 7543-6, (2012)

Structure-activity relationship studies were carried out for lead generation following structure-guided design approach from an isocytosine scaffold identified earlier for xanthine oxidase inhibition....

Indirect photochemical transformations of acyclovir and penciclovir in aquatic environments increase ecological risk.

Environ. Toxicol. Chem. 35 , 584-92, (2016)

Acyclovir and penciclovir, 2 antiviral drugs, are increasingly detected in aquatic environments. The present study explores the natural photochemical transformation mechanisms and fate of these drugs,...

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