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7,8-二甲基咯嗪

7,8-二甲基咯嗪用途

亮氨酸是核黄素的光降解产物,是人体内的一种内源性化合物。Lumichrome通过p53依赖机制抑制人肺癌细胞生长并诱导凋亡[1][2]。

7,8-二甲基咯嗪名称

[ CAS 号 ]:
1086-80-2

[ 中文名 ]:
光色素

[ 英文名 ]:
LUMICHROME

[中文别名 ]:

7,8-二甲基咯嗪

[英文别名 ]:

MFCD00005021
7,8-Dimethylalloxazine
LUM
flavins
7,8-dimethyl-1H-benzo[g]pteridine-2,4-dione
6,7-DIMETHYLALLOXAZINE
EINECS 214-120-8
Benzo[g]pteridine-2,4(1H,3H)-dione,7,8-dimethyl
7,8-dimethyl-benzo[g]pteridine-2,4(1H,3H)-dione

7,8-二甲基咯嗪生物活性

[ 描述 ]:

亮氨酸是核黄素的光降解产物,是人体内的一种内源性化合物。Lumichrome通过p53依赖机制抑制人肺癌细胞生长并诱导凋亡[1][2]。

[ 相关类别 ]:

信号通路 >> 细胞凋亡 >> 细胞凋亡

研究领域 >> 癌症

[ 靶点 ]

Human Endogenous Metabolite

[参考文献]

[1]. Bergh VJ, et al. Influence of formulation on photoinactivation of bacteria by lumichrome. Pharmazie. 2015;70(9):574-580.

[2]. Chantarawong W, et al. Lumichrome Inhibits Human Lung Cancer Cell Growth and Induces Apoptosis via a p53-Dependent Mechanism. Nutr Cancer. 2019;71(8):1390-1402.

7,8-二甲基咯嗪物理化学性质

[ 密度 ]:
1.388g/cm3

[ 熔点 ]:
300 °C

[ 分子式 ]:
C₁₂H₁₀N₄O₂

[ 分子量 ]:
242.23300

[ 精确质量 ]:
242.08000

[ PSA ]:
91.50000

[ LogP ]:
0.77640

[ 外观性状 ]:
固体

[ 折射率 ]:
1.66

[ 储存条件 ]:
室温

[ 稳定性 ]:
Stable. Incompatible with strong oxidizing agents. Combustible.

7,8-二甲基咯嗪MSDS

7,8-二甲基咯嗪安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2933990090

7,8-二甲基咯嗪合成路线

7,8-二甲基咯嗪海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

7,8-二甲基咯嗪文献

Enhanced Indirect Photochemical Transformation of Histidine and Histamine through Association with Chromophoric Dissolved Organic Matter.

Environ. Sci. Technol. 49 , 5511-9, (2015)

Photochemical transformations greatly affect the stability and fate of amino acids (AAs) in sunlit aquatic ecosystems. Whereas the direct phototransformation of dissolved AAs is well investigated, the...

The B vitamins nicotinamide (B3) and riboflavin (B2) stimulate metamorphosis in larvae of the deposit-feeding polychaete Capitella teleta: implications for a sensory ligand-gated ion channel.

PLoS ONE 9(11) , e109535, (2014)

Marine sediments can contain B vitamins, presumably incorporated from settled, decaying phytoplankton and microorganisms associated with decomposition. Because B vitamins may be advantageous for the e...

Molecular and functional characterization of riboflavin specific transport system in rat brain capillary endothelial cells.

Brain Res. 1468 , 1-10, (2012)

Riboflavin is an important water soluble vitamin (B2) required for metabolic reactions, normal cellular growth, differentiation and function. Mammalian brain cells cannot synthesize riboflavin and mus...

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