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核黄素

核黄素用途

Riboflavin(vitamin B2)是极易吸收的微量营养素。

核黄素名称

[ CAS 号 ]:
83-88-5

[ 中文名 ]:
维生素B2

[ 英文名 ]:
Riboflavine

[中文别名 ]:

[英文别名 ]:

6,7-dimethyl-9-D-ribitylisoalloxazine
riboflavine
Flavin BB
Hibon
Russupteridine Yellow III
VITAMIN B2
(-)-Riboflavin
Lactoflavin
Riboflavin (B2)
Beflavin

核黄素生物活性

[ 描述 ]:

Riboflavin(vitamin B2)是极易吸收的微量营养素。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 其他

[参考文献]

[1]. Long, Q., et al., Riboflavin biosynthetic and regulatory factors as potential novel anti-infective drug targets. Chem Biol Drug Des, 2010. 75(4): p. 339-47.

[2]. Zempleni, J., J.R. Galloway, and D.B. McCormick, Pharmacokinetics of orally and intravenously administered riboflavin in healthy humans. Am J Clin Nutr, 1996. 63(1): p. 54-66.

[3]. Bertollo, C.M., et al., Characterization of the antinociceptive and anti-inflammatory activities of riboflavin in different experimental models. Eur J Pharmacol, 2006. 547(1-3): p. 184-91.

[相关活性小分子]

核黄素物理化学性质

[ 密度 ]:
1.7±0.1 g/cm3

[ 沸点 ]:
715.6±70.0 °C at 760 mmHg

[ 熔点 ]:
290 °C (dec.)(lit.)

[ 分子式 ]:
C₁₇H₂₀N₄O₆

[ 分子量 ]:
376.364

[ 闪点 ]:
386.6±35.7 °C

[ 精确质量 ]:
376.138275

[ PSA ]:
161.56000

[ LogP ]:
-2.01

[ 外观性状 ]:
黄色至橙色/黄色结晶粉末

[ 蒸汽压 ]:
0.0±2.4 mmHg at 25°C

[ 折射率 ]:
1.733

[ 储存条件 ]:
2~8°C

[ 水溶解性 ]:
0.07 g/L (20 ºC)

核黄素MSDS

详细MSDS(安全技术说明书)

核黄素毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VJ1400000

CHEMICAL NAME :: Riboflavine

CAS REGISTRY NUMBER :: 83-88-5

LAST UPDATED :: 199701

DATA ITEMS CITED :: 11

MOLECULAR FORMULA :: C17-H20-N4-O6

MOLECULAR WEIGHT :: 376.41

WISWESSER LINE NOTATION :: T C666 BN DNVMV INJ B1YQYQYQ1Q L1 M1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 560 mg/kg

TOXIC EFFECTS :: Behavioral - food intake (animal) Kidney, Ureter, Bladder - urine volume decreased Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Sex chromosome loss and nondisjunction

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 100 mg/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 373,1,1997 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 67410 No. of Facilities: 1890 (estimated) No. of Industries: 8 No. of Occupations: 22 No. of Employees: 24319 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 67410 No. of Facilities: 2923 (estimated) No. of Industries: 15 No. of Occupations: 45 No. of Employees: 74790 (estimated) No. of Female Employees: 35023 (estimated)

核黄素安全信息

[ 符号 ]:

GHS02, GHS06, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H301 + H311 + H331-H370

[ 警示性声明 ]:
P210-P260-P280-P301 + P310-P311

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
F,T

[ 风险声明 (欧洲) ]:
11-23/24/25-39/23/24/25

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
UN1230 - class 3 - PG 2 - Methanol, solution

[ WGK德国 ]:
1

[ RTECS号 ]:
VJ1400000

[ 海关编码 ]:
2936230000

核黄素合成路线

详细合成路线

核黄素上下游产品

核黄素上游产品

核黄素下游产品

核黄素制备

1.合成法D-核糖与3，4-二甲基苯胺经缩合、催化氢化得核糖胺，后者与重氮盐偶合、巴比妥酸环合即得本品

2.发酵法以葡萄糖、玉米浆、无机盐等为培养基，用特种活性菌阿氏假囊酵母(Eremothecium ashbyii)于28℃深层发酵培养9d，发酵液中约含6～8g/L的核黄素产品。提取收率为60%～70

[制取方法]以稻谷粉、小麦粉、酵母粉等为原料，经酵母或基因工程菌发酵制得。

3.以葡萄糖、玉米浆、无机盐等为培养基，用特种活性菌深层发酵制得。也可由3,4-二甲基苯胺与D-核糖缩合，经催化加氢、偶合、还原、成环得到维生素B2。

4.以葡萄糖、玉米浆、无机盐等为培养基，用特种活性菌深层发酵制得。也可由3,4-二甲基苯胺与D-核糖缩合，经催化加氢、偶合、还原、成环制得。

5.（1）微生物法　在培养基中接种，发酵即得VB2。
（2）合成法　以葡萄糖为原料经氧化、成盐、转化、酸化、内酯化、缩合、催化氢化、环合等过程制得 VB2。

核黄素海关

[ 海关编码 ]: 2936230000

[ 申报要素 ]: 品名, 成分含量, 用途, 包装, 是否吸附于载体(如硅胶)

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验

[ Summary ]:
2936230000. unmixed vitaming b2 and deratives(whether or not dissolved in solvents). VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:4.0%. General tariff:20.0%

核黄素文献

Tissue vitamin concentrations are maintained constant by changing the urinary excretion rate of vitamins in rats' restricted food intake.

Biosci. Biotechnol. Biochem. 78(12) , 2102-9, (2014)

We previously reported that mild food restriction induces a reduction in tryptophan-nicotinamide conversion, which helps to explain why death secondary to pellagra is pandemic during the hungry season...

Effect of concentrate feeder design on performance, eating and animal behavior, welfare, ruminal health, and carcass quality in Holstein bulls fed high-concentrate diets.

J. Anim. Sci. 93 , 3018-33, (2015)

A total of 240 Holstein bulls (121 ± 2.0 kg initial BW; 99 ± 1.0 d of age), from 2 consecutive fattening cycles, were randomly allocated in 1 of 6 pens and assigned to 1 of the 3 treatments consisting...

Hinokitiol Exerts Anticancer Activity through Downregulation of MMPs 9/2 and Enhancement of Catalase and SOD Enzymes: In Vivo Augmentation of Lung Histoarchitecture.

Molecules 20 , 17720-34, (2015)

Melanoma is extremely resistant to chemotherapy and the death rate is increasing hastily worldwide. Extracellular matrix promotes the migration and invasion of tumor cells through the production of ma...

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核黄素