亚硝酸乙酯

亚硝酸乙酯用途

【用途一】
亚硝酸乙酯在农药生产上用于合成有机磷杀虫剂辛硫磷的中间体α-肟钠苯乙腈，在医药工业用于制备氯磷定药物。
【用途二】
GB 2760一96规定为暂时允许使用的食用香料。主要用以配制朗姆酒、白兰地酒和樱桃、草莓、菠萝等水果型香精。
【用途三】
在日用品香精中极少应用，一般是用于盥用水或水剂的加香中，取其扩散力好，以及在头香中提供酒香，适用于男用加香产品。食用香精中如樱桃、草莓、凤梨等果香和白酒、白兰地、朗姆等酒香以及烟草香精中亦可用之。通常是先配成4%乙醇溶液，然后应用。
【用途四】
该品为医药氯磷定的中间体。

亚硝酸乙酯名称

[ CAS 号 ]:
109-95-5

[ 中文名 ]:
亚硝酸乙酯

[ 英文名 ]:
Ethanol solution

[中文别名 ]:

亞硝酸乙酯

[英文别名 ]:

Nitrosyl ethoxide
Spirit of nitrous ether
Aethylnitrit
Salpetrigsaeure-aethylester
Salpetrigaether
EINECS 203-722-6
Hyponitrous ether
Nitrous ethyl ether
Nitrous ether
MFCD00010257

亚硝酸乙酯物理化学性质

[ 密度 ]:
0.792 g/mL at 25 °C

[ 沸点 ]:
20ºC at 760 mmHg

[ 分子式 ]:
C₂H₅NO₂

[ 分子量 ]:
75.06660

[ 闪点 ]:
59 °F

[ 精确质量 ]:
75.03200

[ PSA ]:
38.66000

[ LogP ]:
0.70430

[ 外观性状 ]:
无色至黄色液体

[ 折射率 ]:
n20/D 1.36

[ 储存条件 ]:
库房通风低温干燥,与氧化剂、酸类分开存放

亚硝酸乙酯MSDS

详细MSDS(安全技术说明书)

亚硝酸乙酯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RA0810000

CHEMICAL NAME :: Nitrous acid, ethyl ester

CAS REGISTRY NUMBER :: 109-95-5

BEILSTEIN REFERENCE NO. :: 1699562

LAST UPDATED :: 199701

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C2-H5-N-O2

MOLECULAR WEIGHT :: 75.08

WISWESSER LINE NOTATION :: ONO2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 160 ppm/4H

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - excitement Lungs, Thorax, or Respiration - cyanosis

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 8,101,1987

TYPE OF TEST :: LC - Lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >200 mg/m3/15M

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 48(1),62,1983

TYPE OF TEST :: LC - Lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: >200 mg/m3/15M

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 48(1),62,1983

亚硝酸乙酯安全信息

[ 符号 ]:

GHS02, GHS07

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H319

[ 警示性声明 ]:
P210-P280-P305 + P351 + P338-P337 + P313-P403 + P235

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
F,Xn,E

[ 风险声明 (欧洲) ]:
R11

[ 安全声明 (欧洲) ]:
S7-S16-S35

[ 危险品运输编码 ]:
UN 1194 3/PG 1

[ RTECS号 ]:
RA0810000

[ 包装等级 ]:
I

[ 危险类别 ]:
3.1

[ 海关编码 ]:
2920909090

亚硝酸乙酯合成路线

详细合成路线

亚硝酸乙酯上下游产品

亚硝酸乙酯上游产品

亚硝酸乙酯下游产品

亚硝酸乙酯制备

1.由乙醇与亚硝酸钠反应而得。将亚硝酸钠溶于热水，冷却后加入乙醇，缓缓注入硫酸，即发生亚硝酸乙酯气体，将其通入用冰盐水冷却的乙醇中吸收，得亚硝酸乙酯的乙醇溶液。

2.其制备方法是由乙醇与亚硝酸钠作用得到亚硝酸乙酯。C2H5OH+NaNO2[H2SO4]→C2H5ONO将亚硝酸钠用热水溶解，待冷却后加入乙醇，缓慢注入硫酸，即发生亚硝酸乙酯气体，通入用冰盐水冷却的乙醇中吸收，即得亚硝酸乙酯的乙醇溶液，按增重法计算，乙醇中的亚硝酸乙酯含量为30％左右。

3.亚硝酸钠在水溶液中用硫酸置换成酸，再与存在于该溶液中的乙醇酯化而成。

亚硝酸乙酯海关

[ 海关编码 ]: 2920909090

[ 中文概述 ]:
2920909090 其他无机酸酯（不包括卤化氢的酯）（包括其盐及它们的卤化，磺化，硝化和亚硝化衍生物）。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2920909090 esters of other inorganic acids of non-metals (excluding esters of hydrogen halides) and their salts; their halogenated, sulphonated, nitrated or nitrosated derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

亚硝酸乙酯文献

Transformation of ethyl alcohol to ethyl nitrite in acidified saliva: possibility of its occurrence in the stomach.

Arch. Biochem. Biophys. 475(2) , 135-9, (2008)

After taking alcoholic beverages, the ethanol is mixed with saliva and then gastric juice. As pH of gastric juice is around 2, the ethanol might be transformed to ethyl nitrite in the stomach by react...

Efficacy of ethyl nitrite in reversing surgical vasospasm.

J. Reconstr. Microsurg. 23(5) , 257-62, (2007)

Vasospasm leading to thrombosis is a major cause of free flap failure. Flap blood flow may improve by application of vasodilating agents to the pedicle. The purpose of this study is to evaluate the ef...

Inhaled ethyl nitrite gas for persistent pulmonary hypertension in infants.

Lancet 360(9350) , 2076-7; author reply 2077, (2002)

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