β-烟酰胺单核苷酸

β-烟酰胺单核苷酸用途

β-Nicotinamide mononucleotide是由烟酰胺磷酸核糖基转移酶从烟酰胺 (NAM) 和磷酸核糖焦磷酸 (PRPP) 产生的NAD +生物合成中的中间体。

β-烟酰胺单核苷酸作用

烟酰胺单核苷酸会转化成体内能量代谢必不可少的“烟酰胺腺嘌呤二核苷酸(NAD)”物质。在小鼠试验中，证实烟酰胺单核苷酸可激活体内一种叫做乙酰化酶的基因，以此发挥延年益寿和治疗糖尿病等效果。NAD是人体原本可以生成的物质，研究证实体内的NAD含量会随着年龄的增加而减少。

β-烟酰胺单核苷酸名称

[ CAS 号 ]:
1094-61-7

[ 中文名 ]:
β-烟酰胺单核苷酸

[ 英文名 ]:
β-Nicotinamide mononucleotide

[中文别名 ]:

[英文别名 ]:

MFCD00038748
Beta-Nicotinamide Mononucleotide
Nicotinamide D-ribonucleotide
NMN zwitterion
EINECS 214-136-5
β-nicotinamide mononucleotide
beta-NMN
Nicotinamide ribonucleotide
NMN

β-烟酰胺单核苷酸生物活性

[ 描述 ]:

β-Nicotinamide mononucleotide是由烟酰胺磷酸核糖基转移酶从烟酰胺 (NAM) 和磷酸核糖焦磷酸 (PRPP) 产生的NAD +生物合成中的中间体。

[ 相关类别 ]:

天然产物 >> 糖和糖苷

研究领域 >> 其他

[ 靶点 ]

Human Endogenous Metabolite

[相关活性小分子]

β-烟酰胺单核苷酸物理化学性质

[ 分子式 ]:
C₁₁H₁₅N₂O₈P

[ 分子量 ]:
334.219

[ 精确质量 ]:
334.056610

[ PSA ]:
176.06000

[ LogP ]:
-3.38

[ 外观性状 ]:
白色至浅黄色粉末至晶体

[ 储存条件 ]:
2-8°C

β-烟酰胺单核苷酸MSDS

β-烟酰胺单核苷酸安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

β-烟酰胺单核苷酸合成路线

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β-烟酰胺单核苷酸文献

Lipopolysaccharide Regulation of Intestinal Tight Junction Permeability Is Mediated by TLR4 Signal Transduction Pathway Activation of FAK and MyD88.

J. Immunol. 195 , 4999-5010, (2015)

Gut-derived bacterial LPS plays an essential role in inducing intestinal and systemic inflammatory responses and have been implicated as a pathogenic factor in necrotizing enterocolitis and inflammato...

A possibility of nutriceuticals as an anti-aging intervention: activation of sirtuins by promoting mammalian NAD biosynthesis.

Pharmacol. Res. 62(1) , 42-7, (2010)

Aging science has recently drawn much attention, and discussions on the possibility of anti-aging medicine have multiplied. One potential target for the development of anti-aging drugs is the SIR2 (si...

The high-resolution crystal structure of periplasmic Haemophilus influenzae NAD nucleotidase reveals a novel enzymatic function of human CD73 related to NAD metabolism.

Biochem. J. 441(1) , 131-41, (2012)

Haemophilus influenzae is a major pathogen of the respiratory tract in humans that has developed the capability to exploit host NAD(P) for its nicotinamide dinucleotide requirement. This strategy is o...

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