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[Des-His1,Glu9]-Glucagon amide

[Des-His1,Glu9]-Glucagon amide用途

[Des-His1,Glu9]-Glucagon amide 是一种有效的胰高血糖素受体的肽拮抗剂,pA2 值为 7.2。 [Des-His1,Glu9]-Glucagon amide 在糖尿病的发病机理研究中有用。

[Des-His1,Glu9]-Glucagon amide名称

[ CAS 号 ]:
110084-95-2

[ 中文名 ]:
des-His1- [Glu9]-胰高血糖素(1-29)酰胺

[ 英文名 ]:
(Des-His1,Glu9)-Glucagon (1-29) amide (human, rat, porcine)

[英文别名 ]:

MFCD00080353
SQGTFTSEYSKYLDSRRAQDFVQWLMNT-NH2

[Des-His1,Glu9]-Glucagon amide生物活性

[ 描述 ]:

[Des-His1,Glu9]-Glucagon amide 是一种有效的胰高血糖素受体的肽拮抗剂,pA2 值为 7.2。 [Des-His1,Glu9]-Glucagon amide 在糖尿病的发病机理研究中有用。

[ 相关类别 ]:

研究领域 >> 代谢疾病

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 胰高血糖素受体

[ 靶点 ]

glucagon receptor[1]

[参考文献]

[1]. Unson CG, et, al. Biological activities of des-His1[Glu9]glucagon amide, a glucagon antagonist. Peptides. 1989 Nov; 10(6): 1171-7.

[Des-His1,Glu9]-Glucagon amide物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 分子式 ]:
C₁₄₈H₂₂₁N₄₁O₄₇S

[ 分子量 ]:
3358.650

[ 精确质量 ]:
3356.588379

[ PSA ]:
1512.05000

[ LogP ]:
-6.53

[ 折射率 ]:
1.676

[Des-His1,Glu9]-Glucagon amide安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[Des-His1,Glu9]-Glucagon amide文献

Glucagon stimulates exocytosis in mouse and rat pancreatic alpha-cells by binding to glucagon receptors.

Mol. Endocrinol. 19 , 198-212, (2005)

Glucagon, secreted by the pancreatic alpha-cells, stimulates insulin secretion from neighboring beta-cells by cAMP- and protein kinase A (PKA)-dependent mechanisms, but it is not known whether glucago...

Glucagon receptors on human islet cells contribute to glucose competence of insulin release.

Diabetologia 43 , 1012-1019, (2000)

Synergism between glucose and cAMP in the stimulation of insulin secretion has been suggested to regulate beta cells. This study assessed the importance of an interaction between glucose and cAMP in t...

Biological activities of des-His1[Glu9]glucagon amide, a glucagon antagonist.

Peptides 10 , 1171, (1989)

Hyperglycemia in diabetes mellitus is generally associated with elevated levels of glucagon in the blood. A glucagon analog, des-His1[Glu9]glucagon amide, has been designed and synthesized and found t...

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