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[Arg8]-催产加压素

[Arg8]-催产加压素用途

[Arg8]-Vasotocin是加压素/催产素激素家族的脊椎动物神经垂体肽。

[Arg8]-催产加压素名称

[ CAS 号 ]:
113-80-4

[ 中文名 ]:
精氨缩宫素

[ 英文名 ]:
(Arg8)-Vasotocin acetate salt

[英文别名 ]:

8-argininevasotocin
arginine-vasopressin
8-Arg-vasotocin
CYS-TYR-ILE-GLN-ASN-CYS-PRO-ARG-GLY-NH2
8-Arginine vasotocin
argiprestocin
[ARG8]-VASOTOCIN
8-L-Arginineoxytocin
VASOTOCIN ARG 8
CYIQNCPRG-NH2

[Arg8]-催产加压素生物活性

[ 描述 ]:

[Arg8]-Vasotocin是加压素/催产素激素家族的脊椎动物神经垂体肽。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 血管加压素受体

研究领域 >> 神经疾病

多肽产品

[相关活性小分子]

[Arg8]-催产加压素物理化学性质

[ 密度 ]:
1.6±0.1 g/cm3

[ 分子式 ]:
C₄₃H₆₇N₁₅O₁₂S₂

[ 分子量 ]:
1050.215

[ 精确质量 ]:
1049.453491

[ PSA ]:
512.03000

[ LogP ]:
-6.27

[ 折射率 ]:
1.713

[ 储存条件 ]:
库房通风低温干燥

[Arg8]-催产加压素毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RS7534500

CHEMICAL NAME :: Oxytocin, 8-L-arginine-

CAS REGISTRY NUMBER :: 113-80-4

LAST UPDATED :: 199706

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C43-H67-N15-O12-S2

MOLECULAR WEIGHT :: 1050.37

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 625 ug/kg

SEX/DURATION :: male 5 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)

REFERENCE :: BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309 W. Clark St., Champaign, IL 61820) V.1- 1969- Volume(issue)/page/year: 37,935,1987

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 80 ug/kg

SEX/DURATION :: female 19 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - menstrual cycle changes or disorders

REFERENCE :: INJFA3 International Journal of Fertility. (Allen Press, 1041 New Hampshire, St., Lawrence, KS 66044) V.1- 1955- Volume(issue)/page/year: 21,65,1976

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 80 ug/kg

SEX/DURATION :: female 1-21 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - abortion

REFERENCE :: INJFA3 International Journal of Fertility. (Allen Press, 1041 New Hampshire, St., Lawrence, KS 66044) V.1- 1955- Volume(issue)/page/year: 21,65,1976

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 120 ug/kg

SEX/DURATION :: male 3 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands

REFERENCE :: INJFA3 International Journal of Fertility. (Allen Press, 1041 New Hampshire, St., Lawrence, KS 66044) V.1- 1955- Volume(issue)/page/year: 19,103,1974

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Unreported

DOSE :: 80 ug/kg

SEX/DURATION :: female 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - uterus, cervix, vagina

REFERENCE :: PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 133,1254,1970

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 24 ug/kg

SEX/DURATION :: male 3 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands

REFERENCE :: INJFA3 International Journal of Fertility. (Allen Press, 1041 New Hampshire, St., Lawrence, KS 66044) V.1- 1955- Volume(issue)/page/year: 19,103,1974