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Illudin M

Illudin M用途

Illudin M 是一种细胞毒性真菌倍半萜,可以从 Omphalotus olearius 蘑菇培养基中分离得到的。Illudin M 能使 DNA 烷基化。Illudin M 具有抗肿瘤活性。

Illudin M名称

[ CAS 号 ]:
1146-04-9

[ 英文名 ]:
Illudin M

[英文别名 ]:

illudin M

Illudin M生物活性

[ 描述 ]:

Illudin M 是一种细胞毒性真菌倍半萜,可以从 Omphalotus olearius 蘑菇培养基中分离得到的。Illudin M 能使 DNA 烷基化。Illudin M 具有抗肿瘤活性。

[ 相关类别 ]:

信号通路 >> 细胞凋亡 >> 细胞凋亡

研究领域 >> 癌症

信号通路 >> 细胞周期/DNA损伤 >> DNA烷基化剂/交联剂

[体外研究]

Illudin M(0.01-10μM；24-120小时)在体外具有细胞毒性和诱导凋亡作用[1]。细胞凋亡分析[1]细胞系：Panc-1胰腺癌、HT-29结肠癌、非恶性包皮成纤维细胞(HFs)浓度：0.01μM、1μM、10μM孵育时间：24小时、48小时、72小时、96小时、120小时结果：肿瘤细胞凋亡诱导率相当(Panc-1 86%,HT-29 48%),但HF中的一个更大(89%)。

[参考文献]

[1]. Rainer Schobert, et al. Conjugates of the fungal cytotoxin illudin M with improved tumour specificity. Bioorg Med Chem. 2008 Sep 15;16(18):8592-7.

[2]. Dr. Philipp Le, et al. A Chemical Proteomic Analysis of Illudin‐Interacting Proteins. Chemistry. 2019 Sep 25; 25(54): 12644–12651.

Illudin M物理化学性质

[ 密度 ]:
1.24g/cm3

[ 沸点 ]:
452.4ºC at 760mmHg

[ 分子式 ]:
C₁₅H₂₀O₃

[ 分子量 ]:
248.31700

[ 闪点 ]:
241.5ºC

[ 精确质量 ]:
248.14100

[ PSA ]:
57.53000

[ LogP ]:
1.74390

[ 蒸汽压 ]:
4.36E-10mmHg at 25°C

[ 折射率 ]:
1.593

Illudin M毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WH0204350

CHEMICAL NAME :: Spiro(cyclopropane-1,5'-(5H)inden)-7'(6'H)-one, 2',3'-dihydro-3'-beta,6'-alpha-dihydroxy-2',2 4',6'-tetramethyl-

CAS REGISTRY NUMBER :: 1146-04-9

LAST UPDATED :: 199612

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C15-H20-O3

MOLECULAR WEIGHT :: 248.35

WISWESSER LINE NOTATION :: L56 FV HXTJ BQ C1 C1 GQ G1 I1 H-& AL3XTJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 15 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 31250 ng/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 215,179,1989