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琥珀磺胺噻唑

琥珀磺胺噻唑用途

Succinylsulfathiazole为磺胺类化合物,是超长效药物。

琥珀磺胺噻唑名称

[ CAS 号 ]:
116-43-8

[ 中文名 ]:
琥珀酰磺胺噻唑

[ 英文名 ]:
succinylsulfathiazole

[中文别名 ]:

[英文别名 ]:

EINECS 204-141-0
Succinanilic acid, 4'-(2-thiazolylsulfamoyl)-
MFCD00022437
succinylsulfathiazole
Succinylsulfathiazole Hydrate
N1-(2-THIAZOLYL)-N4-SUCCINOYLSULFANILAMIDE
N4-Succinyl-N-(2-thiazolyl)sulfanilamide Hydrate
N4-Succinyl-N-(2-thiazolyl)sulfanilamide
p-2-Thiazolylsulfamoylsuccinanilic acid

琥珀磺胺噻唑生物活性

[ 描述 ]:

Succinylsulfathiazole为磺胺类化合物,是超长效药物。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 细菌

研究领域 >> 感染

[相关活性小分子]

琥珀磺胺噻唑物理化学性质

[ 密度 ]:
1.6±0.1 g/cm3

[ 熔点 ]:
187 - 193ºC

[ 分子式 ]:
C₁₃H₁₃N₃O₅S₂

[ 分子量 ]:
355.389

[ 精确质量 ]:
355.029663

[ PSA ]:
162.08000

[ LogP ]:
0.68

[ 折射率 ]:
1.679

[ 储存条件 ]:
室温，干燥

琥珀磺胺噻唑MSDS

琥珀磺胺噻唑毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WM4767000

CHEMICAL NAME :: Succinanilic acid, 4'-(2-thiazolylsulfamoyl)-

CAS REGISTRY NUMBER :: 116-43-8

BEILSTEIN REFERENCE NO. :: 0349989

LAST UPDATED :: 199612

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C13-H13-N3-O5-S2

MOLECULAR WEIGHT :: 355.41

WISWESSER LINE NOTATION :: T5N CSJ BMSWR DMV2VQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5700 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 75,231,1942

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 7,151,1981 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81640 No. of Facilities: 58 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 230 (estimated)

琥珀磺胺噻唑安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H317

[ 警示性声明 ]:
P280

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful;

[ 风险声明 (欧洲) ]:
R42/43

[ 安全声明 (欧洲) ]:
S22-S36/37-S45

[ 危险品运输编码 ]:
3249

[ WGK德国 ]:
3

[ RTECS号 ]:
WM4767000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

[ 海关编码 ]:
2935009090

琥珀磺胺噻唑合成路线

琥珀磺胺噻唑上下游产品

琥珀磺胺噻唑上游产品

琥珀磺胺噻唑下游产品

琥珀磺胺噻唑制备

由对琥珀酰氨基苯磺酰氯与乙氨基噻唑为原料制得。

琥珀磺胺噻唑海关

[ 海关编码 ]: 2935009090

[ 中文概述 ]:
2935009090 其他磺（酰）胺. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:35.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

琥珀磺胺噻唑文献

Arsenic urinary speciation in Mthfr deficient mice injected with sodium arsenate.

Toxicol. Lett. 215(3) , 214-8, (2012)

In most mammalian species, arsenic biotransformation occurs primarily by biomethylation and reduction reactions, with dimethylarsinic acid being the predominant metabolite excreted in the urine. Methy...

Prediction of drug intestinal absorption by new linear and non-linear QSPR.

Eur. J. Med. Chem. 46 , 218-28, (2011)

In order to minimize the high attrition rate that usually characterizes drug research and development projects, current medicinal chemists aim to characterize both pharmacological and ADME profiles at...

Folate deficiency induces neurodegeneration and brain dysfunction in mice lacking uracil DNA glycosylase.

J. Neurosci. 28 , 7219-7230, (2008)

Folate deficiency and resultant increased homocysteine levels have been linked experimentally and epidemiologically with neurodegenerative conditions like stroke and dementia. Moreover, folate deficie...

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