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(2E)-3-苯基-N-[2,2,2-三氯-1-[[[(4-氯苯基)氨基]硫代甲酰基]氨基]乙基]-2-丙烯酰胺

用途

Sal003是eIF2_alpha_ phosphatase高效细胞渗透性抑制剂,Salubrinal的水溶性类似物。

名称

[ CAS 号 ]:
1164470-53-4

[ 中文名 ]:
(2E)-3-苯基-N-[2,2,2-三氯-1-[[[(4-氯苯基)氨基]硫代甲酰基]氨基]乙基]-2-丙烯酰胺

[ 英文名 ]:
Sal003

[英文别名 ]:

Sal003

生物活性

[ 描述 ]:

Sal003是eIF2_alpha_ phosphatase高效细胞渗透性抑制剂,Salubrinal的水溶性类似物。

[ 相关类别 ]:

信号通路 >> 代谢酶/蛋白酶 >> 磷酸酶

研究领域 >> 癌症

[参考文献]

[1]. Xia F, et al. Inhibition of cholesterol biosynthesis impairs insulin secretion and voltage-gated calcium channel function in pancreatic beta-cells. Endocrinology. 2008 Oct;149(10):5136-45.

[2]. Horie M, et al. Effects of NB-598, a potent squalene epoxidase inhibitor, on the apical membrane uptake of cholesterol and basolateral membrane secretion of lipids in Caco-2 cells. Biochem Pharmacol. 1993 Jul 20;46(2):297-305.

[3]. Horie M, et al. An inhibitor of squalene epoxidase, NB-598, suppresses the secretion of cholesterol and triacylglycerol and simultaneously reduces apolipoprotein B in HepG2 cells. Biochim Biophys Acta. 1993 May 20;1168(1):45-51.

[相关活性小分子]

物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 分子式 ]:
C₁₈H₁₅Cl₄N₃OS

[ 分子量 ]:
463.208

[ 精确质量 ]:
460.968994

[ PSA ]:
95.78000

[ LogP ]:
6.20

[ 外观性状 ]:
粉末

[ 折射率 ]:
1.694

[ 储存条件 ]:
-20℃

安全信息

[ 符号 ]:

GHS09

[ 信号词 ]:
Warning

[ 危害声明 ]:
H410

[ 警示性声明 ]:
P273-P501

[ 危害码 (欧洲) ]:
N

[ 危险品运输编码 ]:
UN 3077 9 / PGIII

文献

Translational Control of Long-Lasting Synaptic Plasticity and Memory

Neuron 61(1) , 10-26, (2009)

Long-lasting forms of synaptic plasticity and memory are dependent on new protein synthesis. Recent advances obtained from genetic, physiological, pharmacological, and biochemical studies provide stro...

Regulation of subtilase cytotoxin-induced cell death by an RNA-dependent protein kinase-like endoplasmic reticulum kinase-dependent proteasome pathway in HeLa cells.

Infect. Immun. 80(5) , 1803-14, (2012)

Shiga-toxigenic Escherichia coli (STEC) produces subtilase cytotoxin (SubAB), which cleaves the molecular chaperone BiP in the endoplasmic reticulum (ER), leading to an ER stress response and then act...

Switching gears: translational mastery of transcription during memory formation.

Neuron 54(2) , 186-9, (2007)

A critical molecular requirement underlying many forms of long-lasting synaptic plasticity and memory is the de novo synthesis of mRNAs and proteins. In a recent paper in Cell, Costa-Mattioli et al. p...

更多文献

(2E)-3-苯基-N-[2,2,2-三氯-1-[[[(4-氯苯基)氨基]硫代甲酰基]氨基]乙基]-2-丙烯酰胺

用途

名称

生物活性

物理化学性质

安全信息

文献

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