黄夹次苷

黄夹次苷用途

Peruvoside 是一种有效的 Src,PI3K,JNK ,STAT,和 EGFR的抑制剂。Peruvoside 诱导细胞凋亡 (apoptosis) 和自噬 (autophagy),在乳腺癌、肺癌、肝癌和白血病中具有广谱的抗肿瘤活性。Peruvoside 对正义 RNA 病毒具有广谱、强效的抗病毒活性。Peruvoside 增加 Gefitinib (HY-50895) 耐药肿瘤细胞 (A549,PC9/gef和H1975) 的敏感性。。

黄夹次苷名称

[ CAS 号 ]:
1182-87-2

[ 中文名 ]:
黄夹次苷

[ 英文名 ]:
peruvoside

[中文别名 ]:

夹次苷

[英文别名 ]:

Cannogenin thevetoside
Encordin
Peruvosid
peruvoside
EINECS 214-659-9
MFCD00133752
Peruvoside from Thevetia neriifolia
Cannogenin |A-L-Thevetoside

黄夹次苷生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 干细胞及 Wnt 通路 >> STAT

信号通路 >> 细胞凋亡 >> 细胞凋亡

研究领域 >> 癌症

信号通路 >> JAK/STAT信号通路 >> EGFR

信号通路 >> JAK/STAT信号通路 >> STAT

信号通路 >> 蛋白酪氨酸激酶 >> EGFR

信号通路 >> PI3K/Akt/mTOR 信号通路 >> PI3K

信号通路 >> 蛋白酪氨酸激酶 >> SRC

信号通路 >> 自噬 >> 自噬

信号通路 >> MAPK/ERK信号通路 >> JNK

[参考文献]

[1]. Lai Y, et al. Peruvoside is a novel Src inhibitor that suppresses NSCLC cell growth and motility by downregulating multiple Src-EGFR-related pathways. Am J Cancer Res. 2022 Jun 15;12(6):2576-2593.

[2]. Reddy D, et al. Peruvoside targets apoptosis and autophagy through MAPK Wnt/β-catenin and PI3K/AKT/mTOR signaling pathways in human cancers. Life Sci. 2020 Jan 15;241:117147. doi: 10.1016/j.lfs.2019.117147. Epub 2019 Dec 9. PMID: 31830480.

[3]. Feng Q, et al. Peruvoside, a Cardiac Glycoside, Induces Primitive Myeloid Leukemia Cell Death. Molecules. 2016 Apr 22;21(4):534.

[4]. Wu KX, et al. The host-targeting compound peruvoside has a broad-spectrum antiviral activity against positive-sense RNA viruses. Acta Pharm Sin B. 2023 May;13(5):2039-2055.

黄夹次苷物理化学性质

[ 密度 ]:
1.31g/cm3

[ 沸点 ]:
731.6ºC at 760 mmHg

[ 熔点 ]:
161-164ºC

[ 分子式 ]:
C₃₀H₄₄O₉

[ 分子量 ]:
548.66

[ 闪点 ]:
236.2ºC

[ 精确质量 ]:
548.29900

[ PSA ]:
131.75000

[ LogP ]:
2.28920

[ 蒸汽压 ]:
1.04E-24mmHg at 25°C

[ 折射率 ]:
1.588

黄夹次苷MSDS

详细MSDS(安全技术说明书)

黄夹次苷毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: FH4915000

CHEMICAL NAME :: Card-20(22)-enolide, 3-((6-deoxy-3-O-methyl-alpha-L-glucopyranosyl)oxy)-14 -hydroxy-19-oxo-, (3-beta,5-beta)-

CAS REGISTRY NUMBER :: 1182-87-2

LAST UPDATED :: 198910

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C30-H44-O9

MOLECULAR WEIGHT :: 548.74

WISWESSER LINE NOTATION :: L E5 B666TJ A1 E1 F- DT5OV EHJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human

DOSE/DURATION :: 24 ug/kg

TOXIC EFFECTS :: Behavioral - anorexia (human) Gastrointestinal - nausea or vomiting

REFERENCE :: IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963- Volume(issue)/page/year: 5,31,1967

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human

DOSE/DURATION :: 39 ug/kg/3D

TOXIC EFFECTS :: Cardiac - pulse rate Gastrointestinal - nausea or vomiting

REFERENCE :: IJMRAQ Indian Journal of Medical Research. (Indian Council of Medical Research, Ansari Nagar, New Delhi 110 029, India) V.1- 1913- Volume(issue)/page/year: 59,271,1971

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Human

DOSE/DURATION :: 4285 ng/kg

TOXIC EFFECTS :: Gastrointestinal - nausea or vomiting Vascular - BP lowering not characterized in autonomic section

REFERENCE :: IJMRAQ Indian Journal of Medical Research. (Indian Council of Medical Research, Ansari Nagar, New Delhi 110 029, India) V.1- 1913- Volume(issue)/page/year: 59,271,1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 145 ug/kg

TOXIC EFFECTS :: Cardiac - arrhythmias (including changes in conduction) Cardiac - change in rate Gastrointestinal - nausea or vomiting

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 126,412,1960

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 710 ug/kg

TOXIC EFFECTS :: Cardiac - arrhythmias (including changes in conduction) Cardiac - change in rate Gastrointestinal - nausea or vomiting

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 126,412,1960

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Bird - pigeon

DOSE/DURATION :: 263 mg/kg

TOXIC EFFECTS :: Cardiac - arrhythmias (including changes in conduction) Cardiac - change in rate Gastrointestinal - nausea or vomiting

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 126,412,1960

黄夹次苷安全信息

[ 危害码 (欧洲) ]:
T

[ 风险声明 (欧洲) ]:
23/24/25

[ 安全声明 (欧洲) ]:
36/37/39-45

[ WGK德国 ]:
3

[ RTECS号 ]:
FH4915000