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罗库溴铵

罗库溴铵用途

溴化Rocuronium是氨基甾体类非去极化的神经肌肉受体抑制剂或肌肉松弛剂。

罗库溴铵名称

[ CAS 号 ]:
119302-91-9

[ 中文名 ]:
罗库溴铵

[ 英文名 ]:
Rocuronium bromide

[中文别名 ]:

[英文别名 ]:

RocuroniuM BroMide IsoMers
Rocuronium bromide
EINECS 214-776-5
Esmeron
(+)-Rocuronium bromide
Org-9426
Pyrrolidinium
Eslax
Zemuron,Esmeron
MFCD00867768

罗库溴铵生物活性

[ 描述 ]:

溴化Rocuronium是氨基甾体类非去极化的神经肌肉受体抑制剂或肌肉松弛剂。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 神经疾病

[参考文献]

[1]. Narimatsu E, Niiya T, Takahashi K, Pralidoxime inhibits paraoxon-induced depression of rocuronium-neuromuscular block in a time-dependentfashion. Am J Emerg Med. 2012 Jul;30(6):901-7.

[2]. Wicks TC. The pharmacology of rocuronium bromide (ORG 9426). AANA J. 1994 Feb;62(1):33-8.

[3]. Wierda JM, Kleef UW, Lambalk LM, The pharmacodynamics and pharmacokinetics of Org 9426, a new non-depolarizing neuromuscular blocking agent, in patients anaesthetized with nitrous oxide, halothane and fentanyl. Can J Anaesth. 1991 May;38(4 Pt 1):430-5.

[4]. Khuenl-Brady K, Castagnoli KP, Canfell PC, The neuromuscular blocking effects and pharmacokinetics of ORG 9426 and ORG 9616 in the cat. Anesthesiology. 1990 Apr;72(4):669-74.

[相关活性小分子]

罗库溴铵物理化学性质

[ 熔点 ]:
162-1640C

[ 分子式 ]:
C₃₂H₅₃BrN₂O₄

[ 分子量 ]:
609.678

[ 精确质量 ]:
608.318848

[ PSA ]:
59.00000

[ LogP ]:
1.30820

[ 外观性状 ]:
白色或灰白色粉末

[ 储存条件 ]:
Room temp

罗库溴铵MSDS

详细MSDS(安全技术说明书)

罗库溴铵安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2934999090

罗库溴铵制备

(2α,3α,5α,16α,17β)-2,3,16,17-二环氧雄甾-17-醇乙酸酯(Ⅰ)和四氢吡咯水溶液回流1h，得到的17-酮(Ⅱ)和硼氢化钠，在甲醇中搅拌，还原得到化合物(Ⅲ)。和吗啡水溶液回流3d，得到化合物(Ⅳ)。部分乙酰化，再和烯丙基溴反应，即得产物。

罗库溴铵海关

[ 海关编码 ]: 2934999090

[ 中文概述 ]:
2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

罗库溴铵文献

Effects of infusion of human methemoglobin solution following hydrogen sulfide poisoning.

Clin. Toxicol. (Phila.) 53(2) , 93-101, (2015)

We have recently reported that infusion of a solution containing methemoglobin (MetHb) during exposure to hydrogen sulfide results in a rapid and large decrease in the concentration of the pool of sol...

Bsm1 vitamin D receptor polymorphism and calcium homeostasis following bariatric surgery.

J. Invest. Surg. 28(1) , 8-17, (2015)

To evaluate the association between the Bsm1 vitamin D receptor polymorphism and the calcium-vitamin D-parathormone axis following bariatric surgery.This cross-sectional study included 86 morbidly obe...

Gingival pain: an unusual side effect of ziprasidone.

BMJ Case Rep. 2013 , doi:10.1136/bcr-2012-007577, (2013)

The patient is a 52-year-old man with schizophrenia who developed severe, unremitting gingival pain after his ziprasidone dosage was increased from 80 to 120 mg. His physical examination and laborator...

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